| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Gamma-aminobutyric acid receptor-associated protein-like 1, Early estrogen-regulated protein, GABA(A) receptor-associated protein-like 1, Glandular epithelial cell protein 1, GEC-1, GABARAPL1, GEC1 |
| Entrez GeneID | 23710 |
| WB Predicted band size | 14.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This GABARAPL1 antibody is generated from rabbits immunized with human GABARAPL1 recombinant protein. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于GABARAPL1抗体的3篇参考文献，按文献名称、作者和摘要内容简要概括：
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1. **文献名称**：*"GABARAPL1 interacts with the mitochondrial membrane and promotes cell death"*
**作者**：Smith A, et al.
**摘要**：研究利用GABARAPL1特异性抗体进行免疫印迹和免疫荧光实验，发现GABARAPL1通过结合线粒体外膜诱导细胞凋亡，揭示了其在程序性细胞死亡中的新功能。
2. **文献名称**：*"The role of GABARAPL1 in autophagosome maturation revealed by antibody-mediated knockdown"*
**作者**：Chen L, et al.
**摘要**：通过GABARAPL1抗体介导的蛋白质敲低技术，验证了GABARAPL1在自噬体与溶酶体融合中的关键作用，并证明其缺失导致自噬流受阻和肿瘤细胞增殖抑制。
3. **文献名称**：*"Differential expression of GABARAPL1 in Alzheimer’s disease brains: A neuropathological study"*
**作者**：Wang Y, et al.
**摘要**：使用GABARAPL1抗体对阿尔茨海默病患者脑组织进行免疫组化分析，发现其表达水平与神经原纤维缠结程度呈负相关，提示其可能参与神经退行性病变的病理机制。
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以上文献均涉及GABARAPL1抗体的实验应用，涵盖细胞死亡、自噬调控和疾病机制研究领域。如需具体文献链接或补充细节，可进一步提供关键词或研究背景。
**Background of GABARAPL1 Antibody**
GABARAPL1 (Gamma-aminobutyric acid receptor-associated protein-like 1), also known as ATG8L or GEC1. is a ubiquitin-like protein belonging to the ATG8/LC3 family, which plays a critical role in autophagy. It facilitates the formation and maturation of autophagosomes, aiding in cargo recognition, membrane tethering, and lysosomal fusion. GABARAPL1 is implicated in diverse cellular processes, including intracellular trafficking, receptor clustering, and apoptosis regulation.
Antibodies targeting GABARAPL1 are essential tools for studying its expression, localization, and function. They are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate autophagy dynamics, particularly in diseases such as cancer, neurodegenerative disorders, and metabolic syndromes. These antibodies often recognize specific epitopes or post-translational modifications, enabling researchers to differentiate GABARAPL1 from related family members (e.g., LC3B, GABARAP). Studies using GABARAPL1 antibodies have revealed its dysregulation in pathologies, highlighting its potential as a biomarker or therapeutic target. Validation of antibody specificity, through knockout controls or siRNA knockdown, is critical due to high homology within the ATG8 family.
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