| WB | DB: 1/500 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Aw-68; HLA class I histocompatibility antigen; A-28 alpha chain; MHC class I antigen A*68; HLA-A; MHC class I antigen HLA A heavy chain |
| Entrez GeneID | 3105 |
| WB Predicted band size | Calculated MW: 41 kDa; Observed MW: 41 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | The antiserum was produced against synthesized peptide derived from human HLA Class I. AA range:204-253 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于Phospho-TAL1(T90)抗体的3篇参考文献，包含文献名称、作者及摘要概括：
1. **"Phosphorylation of TAL1 at threonine 90 regulates its transcriptional activity in hematopoiesis"**
- **作者**: Sanda T. et al.
- **摘要**: 研究揭示TAL1转录因子在T90位点的磷酸化通过促进其与转录共激活因子(如p300)的相互作用，增强其在造血干细胞分化中的转录活性，并利用Phospho-TAL1(T90)抗体验证了该修饰在白血病细胞中的功能。
2. **"AKT-mediated phosphorylation of TAL1 modulates its oncogenic potential in T-cell acute lymphoblastic leukemia"**
- **作者**: Reynaud D. et al.
- **摘要**: 本文发现AKT激酶通过磷酸化TAL1的T90位点，抑制其泛素化降解，从而稳定TAL1蛋白并驱动T细胞白血病的发生。研究使用Phospho-TAL1(T90)抗体证实了磷酸化水平与患者预后的相关性。
3. **"Dynamic phosphorylation of TAL1 regulates erythroid differentiation via chromatin remodeling"**
- **作者**: Huang Y. et al.
- **摘要**: 通过ChIP-seq和功能实验，作者证明T90位点的磷酸化动态调控TAL1与染色质结合的能力，影响红系分化关键基因的表达，Phospho-TAL1(T90)抗体在此研究中用于检测分化过程中的修饰变化。
(注：以上文献为示例性质，实际文献需根据具体数据库检索结果调整。)
The Phospho-TAL1(T90) antibody is a specialized tool used to detect the phosphorylated form of TAL1 (T-cell acute lymphocytic leukemia protein 1), a key transcription factor in hematopoiesis. TAL1. also known as SCL (stem cell leukemia), belongs to the basic helix-loop-helix (bHLH) family and plays a critical role in regulating erythroid, myeloid, and megakaryocytic differentiation. Its activity is tightly controlled by post-translational modifications, including phosphorylation. The phosphorylation of TAL1 at threonine 90 (T90) modulates its interactions with cofactors such as GATA1 or E-proteins, influencing its ability to activate or repress target genes involved in cell proliferation, survival, and differentiation.
This antibody specifically recognizes TAL1 when phosphorylated at T90. enabling researchers to study the activation status and regulatory mechanisms of TAL1 in both normal and pathological contexts. Dysregulation of TAL1. including aberrant phosphorylation, is implicated in T-cell acute lymphoblastic leukemia (T-ALL), where TAL1 overexpression or fusion proteins drive oncogenic signaling. The Phospho-TAL1(T90) antibody is widely used in techniques like Western blotting, immunoprecipitation, and immunofluorescence to investigate TAL1's role in hematopoietic development, leukemogenesis, and response to therapeutic agents. Its application helps elucidate how phosphorylation fine-tunes TAL1’s transcriptional activity, offering insights into disease mechanisms and potential targets for intervention.
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