首页 / 产品 / 抗体 / 一抗

Rabbit Polyclonal NKRF Antibody

  • 中文名: NKRF抗体
  • 别    名: NF-kappa-B-repressing factor, NFkB-repressing factor, Protein ITBA4, Transcription factor NRF, NKRF, ITBA4, NRF
货号: IPDX30384
Price: ¥1180
数量:
大包装询价

验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesNF-kappa-B-repressing factor, NFkB-repressing factor, Protein ITBA4, Transcription factor NRF, NKRF, ITBA4, NRF
Entrez GeneID55922
WB Predicted band size77.7kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis NKRF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 205-233 amino acids from the Central region of human NKRF.
FormulationPurified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) .

+ +

参考文献

以下是关于NKRF(NF-κB Repressing Factor)抗体的3篇虚构参考文献示例(基于领域知识模拟,非真实文献):

---

1. **文献名称**:*NKRF Antibody-Based Detection Reveals Its Role in Suppressing Inflammatory Responses*

**作者**:Smith J, et al.

**摘要**:本研究利用特异性NKRF抗体,通过免疫沉淀和Western blot技术,证实NKRF通过与NF-κB p50亚基结合抑制促炎基因表达。实验表明,NKRF在巨噬细胞中高表达,并在LPS刺激后通过核转位调控炎症反应。

2. **文献名称**:*Development of a Monoclonal Antibody Against NKRF for Tumor Microenvironment Analysis*

**作者**:Lee H, et al.

**摘要**:作者开发了一种高特异性小鼠抗人NKRF单克隆抗体,用于免疫组化分析。研究发现,NKRF在多种实体瘤的间质细胞中高表达,并通过抑制NF-κB通路降低肿瘤细胞的侵袭性,提示其作为癌症治疗靶点的潜力。

3. **文献名称**:*NKRF Antibody Identifies Its Epigenetic Silencing in Autoimmune Disorders*

**作者**:Garcia R, et al.

**摘要**:通过NKRF抗体染色及ChIP-seq分析,发现自身免疫性疾病患者T细胞中NKRF表达显著降低,且其启动子区域呈现高甲基化状态。恢复NKRF表达可缓解NF-κB过度活化,为治疗提供新思路。

---

注:以上文献为模拟内容,实际研究中请通过PubMed、Google Scholar等平台检索真实文献。

背景信息

The NF-κB Repressing Factor (NKRF) antibody is a tool used to study NKRF, a transcriptional regulator that suppresses NF-κB-mediated inflammatory responses. NKRF binds to specific DNA sequences (e.g., NRE motifs) or interacts with co-repressors to inhibit NF-κB activation, playing a critical role in balancing immune and stress responses. Dysregulation of NKRF is linked to chronic inflammation, autoimmune disorders, and cancer. Researchers employ NKRF antibodies in techniques like Western blotting, immunohistochemistry, and chromatin immunoprecipitation (ChIP) to detect NKRF expression, localization, and DNA-binding activity in cells or tissues. These studies help elucidate NKRF's role in pathways like TLR/IL-1R signaling and its crosstalk with oncogenic or anti-apoptotic mechanisms. The antibody's specificity is validated using knockout controls, ensuring reliability in experimental models ranging from immune cells to tumor samples. Understanding NKRF's function via such antibodies may inform therapeutic strategies targeting NF-κB hyperactivity in diseases like rheumatoid arthritis or lymphoma.

客户数据及评论

折叠内容

大包装询价

×