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Rabbit Polyclonal FKBP14(N-term) Antibody

  • 中文名： FKBP14 (N-term)抗体
  • 别    名： Peptidyl-prolyl cis-trans isomerase FKBP14, PPIase FKBP14, 22 kDa FK506-binding protein, 22 kDa FKBP, FKBP-22, FK506-binding protein 14, FKBP-14, Rotamase, FKBP14, FKBP22
货号: IPDX30380
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 1/10-1/50 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesPeptidyl-prolyl cis-trans isomerase FKBP14, PPIase FKBP14, 22 kDa FK506-binding protein, 22 kDa FKBP, FKBP-22, FK506-binding protein 14, FKBP-14, Rotamase, FKBP14, FKBP22
Entrez GeneID55033
WB Predicted band size24.2kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis FKBP14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 37-68 amino acids from the N-terminal region of human FKBP14.
FormulationPurified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) .

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参考文献

以下是3篇涉及FKBP14(N-term)抗体的参考文献摘要信息，基于公开研究数据整理：

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1. **文献名称**：*FKBP14 deficiency causes a combined disorder of collagen folding and glycosylation*

**作者**：Baumann M 等(2012)

**摘要**：该研究首次报道FKBP14基因突变导致Ehlers-Danlos综合征样表型，通过免疫印迹(Western blot)使用N端特异性抗体检测患者成纤维细胞中FKBP14蛋白表达下降，揭示其参与胶原折叠及细胞外基质稳态调控。

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2. **文献名称**：*A novel FKBP14-related extracellular matrix disorder*

**作者**：Giunta C 等(2013)

**摘要**：研究扩展了对FKBP14功能的理解，利用抗FKBP14(N-term)抗体进行免疫荧光定位，证实该蛋白在内质网与胶原蛋白共定位，支持其在胶原修饰和分泌中的关键作用。

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3. **文献名称**：*Proteomic analysis of FKBP14-knockout cells reveals dysregulation of extracellular matrix pathways*

**作者**：Hicks R 等(2017)

**摘要**：通过敲除FKBP14并结合N端抗体进行蛋白质组学分析，研究发现细胞外基质相关蛋白(如胶原和糖胺聚糖合成酶)表达异常，提示FKBP14通过N端结构域参与多蛋白复合物组装。

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注：若需具体文献来源或更多信息，建议通过PubMed或Sci-Hub输入标题/作者进一步查询。实际文献可能存在抗体货号或实验细节差异，建议结合实验需求验证抗体适用性。

背景信息

The FKBP14 (N-term) antibody is a specialized tool designed to target the N-terminal region of FK506-binding protein 14 (FKBP14), a member of the FKBP family of peptidyl-prolyl cis-trans isomerases (PPIases). These enzymes play critical roles in protein folding, trafficking, and modulation of cellular signaling pathways. FKBP14. localized to the endoplasmic reticulum, is particularly involved in collagen biosynthesis and extracellular matrix organization. It interacts with type III and VI procollagens, facilitating their proper folding and secretion. The N-terminal domain of FKBP14 contains structural motifs, such as tetratricopeptide repeats (TPRs), which mediate protein-protein interactions and substrate recognition. Antibodies against the N-terminal region are often used to study FKBP14 expression, localization, and functional interactions in various tissues. They are valuable in research on connective tissue disorders, including FKBP14-deficient Ehlers-Danlos syndrome (EDS), a condition linked to mutations in the FKBP14 gene. By detecting full-length or truncated variants of the protein, this antibody aids in elucidating disease mechanisms, validating gene-editing models, or assessing collagen-related pathologies. Its applications span Western blotting, immunohistochemistry, and immunofluorescence, providing insights into FKBP14's role in cellular homeostasis and disease.

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