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Rabbit Polyclonal CTSF(CenterD276) Antibody

  • 中文名: CTSF (Center D276)抗体
  • 别    名: Cathepsin F, CATSF, CTSF
货号: IPDX30379
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 1/10-1/50 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesCathepsin F, CATSF, CTSF
Entrez GeneID8722
WB Predicted band size53.4kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis CTSF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 261-290 amino acids from the Central region of human CTSF.
FormulationPurified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) .

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参考文献

以下是关于CTSF(组织蛋白酶F)抗体的3篇示例参考文献(注:以下内容为虚构示例,仅供参考):

1. **《CTSF抗体在神经退行性疾病中的表达分析》**

作者:Smith A, et al.

摘要:本研究利用CTSF(克隆号D276)抗体,通过免疫组化技术检测了阿尔茨海默病患者脑组织中CTSF的分布。结果显示,CTSF在溶酶体功能障碍相关的神经元中表达显著升高,提示其可能与tau蛋白异常聚集有关。

2. **《新型CTSF单克隆抗体的开发及其在肿瘤诊断中的应用》**

作者:Johnson R, et al.

摘要:文章报道了一种高特异性的CTSF单克隆抗体(D276克隆)的制备方法,并通过Western blot和流式细胞术验证了其在结直肠癌组织中的灵敏度和特异性。该抗体可作为潜在的肿瘤标志物检测工具。

3. **《组织蛋白酶F在尼曼-匹克病中的功能研究》**

作者:Wang L, et al.

摘要:通过CTSF抗体(Center D276)进行免疫荧光染色,研究发现CTSF在尼曼-匹克病模型小鼠的溶酶体中活性降低,导致脂质代谢紊乱,为疾病机制提供了新见解。

(注:以上文献为模拟示例,实际引用需查询PubMed等数据库。)

背景信息

The CTSF (Center D276) antibody is a monoclonal antibody specifically designed to detect cathepsin F (CTSF), a lysosomal cysteine protease belonging to the papain family. CTSF is encoded by the *CTSF* gene and plays a critical role in intracellular protein degradation within lysosomes, contributing to antigen processing, extracellular matrix remodeling, and cellular homeostasis. Dysregulation of CTSF has been implicated in various pathologies, including cancer, neurodegenerative disorders, and lysosomal storage diseases. The Center D276 clone targets an epitope near residue D276 of human CTSF, enabling specific recognition of both precursor and mature forms of the enzyme in applications such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Validated for use in human and mouse samples, this antibody is particularly valuable for studying CTSF expression patterns in normal and diseased tissues, as well as its role in lysosomal function and disease mechanisms. Its specificity is often confirmed through knockout (KO) validation or siRNA-mediated silencing. Researchers utilize this tool to explore CTSF's involvement in immune regulation, tumor progression, and neurodegenerative processes, making it a key reagent in biomedical research focused on lysosomal biology and related disorders.

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