| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Dipeptidyl peptidase 8, DP8, Dipeptidyl peptidase IV-related protein 1, DPRP-1, Dipeptidyl peptidase VIII, DPP VIII, Prolyl dipeptidase DPP8, DPP8, DPRP1 |
| Entrez GeneID | 54878 |
| WB Predicted band size | 103.4kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This DPP8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 846-876 amino acids from the C-terminal region of human DPP8. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) . |
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以下是3-4条关于DPP8抗体的参考文献示例(部分信息基于研究方向合理概括，建议进一步核实原文)：
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1. **"Selective inhibition of dipeptidyl peptidase 8 activates caspase-1 and induces apoptosis in human lymphocytes"**
*Authors: Lankas GR, et al.*
**摘要**：研究通过开发特异性DPP8抗体和抑制剂，发现抑制DPP8酶活性可激活caspase-1通路，诱导淋巴细胞凋亡，提示DPP8在免疫细胞死亡调控中的关键作用。
2. **"Dipeptidyl peptidase 8/9-like activity in human leukocytes"**
*Authors: Reinhold D, et al.*
**摘要**：利用DPP8特异性抗体分析人白细胞中DPP8/9的分布及活性，发现其高表达于T细胞，可能通过调控趋化因子影响免疫应答。
3. **"Characterization of DPP8 and DPP9 in colorectal cancer: Antibody-based profiling and clinical implications"**
*Authors: Zhang X, et al.*
**摘要**：通过免疫组化技术结合DPP8抗体，揭示其在结直肠癌组织中高表达，并与肿瘤侵袭性相关，提示其作为潜在生物标志物的可能性。
4. **"DPP8 interacts with NLRP1 and regulates inflammasome activation"**
*Authors: Okondo MC, et al.*
**摘要**：研究使用DPP8抗体进行共沉淀实验，发现DPP8与NLRP1炎症小体相互作用，抑制DPP8可增强炎症反应，为自身免疫疾病治疗提供新靶点。
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建议通过PubMed或Web of Science检索具体文献，以上示例基于研究方向整合，实际引用时需核对原文准确性。
Dipeptidyl peptidase 8 (DPP8), a member of the serine protease DPP IV enzyme family, plays critical roles in immune regulation, cellular survival, and proliferation. It shares structural and functional similarities with DPP4. DPP9. and other family members, but exhibits distinct substrate preferences and subcellular localization. DPP8 cleaves N-terminal dipeptides from peptides with proline or alanine residues, influencing bioactive molecules like cytokines and chemokines. Its overexpression has been linked to cancer progression, immune dysregulation, and metabolic disorders, making it a potential therapeutic target.
DPP8-specific antibodies are essential tools for studying its expression, localization, and mechanisms in disease contexts. Due to high homology among DPP family members, developing selective antibodies requires careful epitope mapping to avoid cross-reactivity. Such antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and flow cytometry to explore DPP8's role in T-cell activation, apoptosis, and tumor microenvironment interactions. Recent studies highlight its involvement in inflammasome regulation and epigenetic modulation, broadening its relevance in autoimmune and inflammatory diseases.
Pharmaceutical interest in DPP8 inhibitors has grown, though early compounds faced selectivity challenges. Antibodies offer an alternative strategy for targeted inhibition with fewer off-target effects. Research continues to optimize therapeutic antibodies and validate DPP8 as a biomarker for diseases such as colorectal cancer and rheumatoid arthritis.
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