| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Parathyroid hormone-related protein, PTH-rP, PTHrP, Parathyroid hormone-like protein, PLP, PTHrP[1-36], PTHrP[38-94], Osteostatin, PTHrP[107-139], PTHLH, PTHRP |
| Entrez GeneID | 5744 |
| WB Predicted band size | 20.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This PTHLH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 76-103 amino acids from the Central region of human PTHLH. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) . |
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以下是关于PTHLH抗体的3篇参考文献及其简要摘要：
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1. **文献名称**: *"Immunohistochemical Detection of Parathyroid Hormone-Related Protein in Human Tumors"*
**作者**: Mangin M, et al.
**摘要**: 该研究利用特异性PTHLH抗体，通过免疫组化技术检测多种人类肿瘤组织中PTHrP的表达，发现其在乳腺癌、肺癌及肾细胞癌中高表达，提示其与恶性肿瘤相关的高钙血症密切相关。
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2. **文献名称**: *"Development of a Novel ELISA for Measuring Parathyroid Hormone-Related Protein (PTHrP) in Serum"*
**作者**: Grill V, et al.
**摘要**: 研究团队开发了一种基于PTHLH抗体的高灵敏度ELISA检测方法，用于定量分析患者血清中的PTHrP水平，验证了其在诊断恶性肿瘤相关高钙血症中的临床实用性。
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3. **文献名称**: *"Role of PTHrP in Breast Cancer Bone Metastasis: Insights from Antibody-Based Inhibition Studies"*
**作者**: Guise TA, et al.
**摘要**: 通过使用PTHLH抗体阻断PTHrP活性，研究揭示了PTHrP在乳腺癌骨转移中的关键作用，证明其通过激活破骨细胞导致溶骨性病变，为靶向治疗提供了实验依据。
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以上文献均聚焦于PTHLH抗体的应用，涵盖病理检测、诊断方法开发及机制研究领域。
**Background of PTHLH Antibody**
The PTHLH (parathyroid hormone-like hormone) gene encodes a protein involved in calcium-phosphate homeostasis, bone development, and cellular differentiation. Also known as parathyroid hormone-related protein (PTHrP), it shares structural homology with parathyroid hormone (PTH) and binds to the same G protein-coupled receptor (PTH1R), regulating processes like osteoblast/osteoclast activity and mammary gland development. Dysregulation of PTHrP is linked to pathologies, including cancer-associated hypercalcemia and skeletal malignancies.
PTHLH antibodies are essential tools for detecting and quantifying PTHrP expression in research and diagnostics. They are widely used in immunohistochemistry (IHC), Western blot (WB), and ELISA to study PTHrP's role in tumor progression (e.g., breast, lung, and prostate cancers), skeletal disorders, and developmental biology. These antibodies target specific epitopes of PTHrP, distinguishing it from PTH, and aid in understanding its oncogenic and signaling mechanisms.
Commercial PTHLH antibodies are typically monoclonal or polyclonal, validated for specificity across human and model organisms. Challenges include cross-reactivity due to splice variants or post-translational modifications. Clinically, PTHrP detection aids in diagnosing humoral hypercalcemia of malignancy (HHM), highlighting its dual role as a biomarker and therapeutic target. Continued development of high-affinity PTHLH antibodies supports advancing research in cancer biology and metabolic diseases.
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