| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Carbonic anhydrase 14, Carbonate dehydratase XIV, Carbonic anhydrase XIV, CA-XIV, CA14 |
| Entrez GeneID | 23632 |
| WB Predicted band size | 37.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This CA14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 51-80 amino acids from the N-terminal region of human CA14. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) . |
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以下是关于CA14 (N-term)抗体的示例参考文献(注：文献为虚拟示例，实际需通过学术数据库验证)：
1. **文献名称**：*Characterization of a Novel Polyclonal Antibody Against the N-Terminal Region of Carbonic Anhydrase XIV*
**作者**：Smith A, et al.
**摘要**：该研究开发了一种针对CA14 N末端的多克隆抗体，通过Western blot和免疫组化验证其特异性，证实其在视网膜和肾脏组织中的高表达，提示其在pH调节中的潜在作用。
2. **文献名称**：*Expression and Localization of Carbonic Anhydrase XIV in the Mouse Brain Using a Specific N-Terminal Antibody*
**作者**：Johnson B, et al.
**摘要**：利用N端特异性抗体探究CA14在小鼠脑组织中的分布，发现其在神经元细胞膜中广泛存在，可能参与维持中枢神经系统的酸碱平衡。
3. **文献名称**：*Role of Carbonic Anhydrase XIV in Retinal Function: Insights from Immunohistochemical Analysis*
**作者**：Lee C, et al.
**摘要**：通过N-term抗体进行免疫组化分析，揭示CA14在视网膜外段的特异性定位，暗示其在光感受器功能中的关键作用。
4. **文献名称**：*Development of Monoclonal Antibodies Targeting Human CA14 N-Terminus for Cancer Biomarker Studies*
**作者**：Zhang D, et al.
**摘要**：报道了一种靶向人CA14 N端的单克隆抗体制备方法，并应用于肿瘤组织样本的蛋白表达检测，验证其作为生物标志物的潜力。
建议通过PubMed或Google Scholar搜索实际文献，使用关键词“CA14 N-terminal antibody”或“Carbonic Anhydrase XIV antibody”获取准确信息。
The CA14 (N-term) antibody is a specific immunological tool designed to detect the N-terminal region of carbonic anhydrase XIV (CA14), a member of the carbonic anhydrase (CA) enzyme family. CAs are zinc-containing metalloenzymes that catalyze the reversible hydration of CO₂ to bicarbonate and protons, playing critical roles in pH regulation, ion transport, and cellular homeostasis. CA14. a transmembrane isoform, is predominantly expressed in tissues such as the kidney, retina, and central nervous system, where it contributes to acid-base balance, fluid secretion, and neuronal signaling.
This antibody is commonly utilized in research to investigate CA14 expression, localization, and function in physiological and pathological contexts. It is validated for applications like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF), often showing reactivity with human and model organism-derived CA14. By targeting the N-terminal domain, the antibody helps distinguish CA14 from other CA isoforms, aiding studies on its unique tissue-specific roles.
Research involving CA14 (N-term) antibody has explored its implications in diseases, including retinal disorders, cancer, and neurological conditions, where altered CA14 expression may influence disease progression. The antibody’s specificity and reliability are typically confirmed through knockout controls or peptide-blocking assays. Host species (e.g., rabbit, mouse) and clonality (monoclonal/polyclonal) vary by product, with storage generally recommended at -20°C. Its use continues to support advances in understanding CA-related mechanisms and therapeutic targeting.
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