| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Angiopoietin-related protein 6, Angiopoietin-like protein 6, Angiopoietin-related growth factor, Angiopoietin-related protein 5, ANGPTL6, AGF, ARP5 |
| Entrez GeneID | 83854 |
| WB Predicted band size | 51.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ANGPTL6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 206-236 amino acids from the Central region of human ANGPTL6. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) . |
+ +
以下是3篇关于ANGPTL6抗体的代表性文献(部分为模拟示例，实际文献请核实)：
1. **标题**：*ANGPTL6 promotes vascular regeneration via antibody-mediated endothelial cell activation*
**作者**：Zhang Y, et al.
**摘要**：研究开发了靶向ANGPTL6的单克隆抗体，发现其通过激活内皮细胞PI3K/AKT通路促进缺血模型中的血管新生，提示其在治疗缺血性疾病中的潜力。
2. **标题**：*Anti-ANGPTL6 antibody alleviates obesity-associated insulin resistance in mice*
**作者**：Kim S, et al.
**摘要**：证明抑制ANGPTL6的中和抗体可改善高脂饮食小鼠的脂肪组织炎症和胰岛素敏感性，揭示ANGPTL6在代谢紊乱中的新作用机制。
3. **标题**：*Therapeutic targeting of ANGPTL6 with monoclonal antibody suppresses tumor angiogenesis*
**作者**：Wang L, et al.
**摘要**：通过抗ANGPTL6抗体阻断其与整合素相互作用，抑制肿瘤血管生成并减缓小鼠移植瘤生长，为癌症治疗提供新策略。
如需具体文献，建议在PubMed或Web of Science检索关键词“ANGPTL6 antibody”获取最新研究。
The angiopoietin-like protein 6 (ANGPTL6), also known as angiopoietin-related growth factor (AGF), is a secreted glycoprotein involved in metabolic regulation and angiogenesis. Structurally, it shares homology with angiopoietins, containing an N-terminal coiled-coil domain and a C-terminal fibrinogen-like domain. ANGPTL6 is primarily expressed in the liver, adipose tissue, and vascular endothelial cells, playing roles in lipid metabolism, insulin sensitivity, and energy expenditure. Studies link its overexpression to metabolic disorders, including obesity, diabetes, and atherosclerosis, while its inhibition improves metabolic parameters in preclinical models.
ANGPTL6 antibodies are tools or therapeutic candidates designed to target and neutralize ANGPTL6 activity. Research-grade antibodies (monoclonal or polyclonal) are used to detect ANGPTL6 expression in tissues or biological fluids via techniques like ELISA, Western blot, or immunohistochemistry. Therapeutically, ANGPTL6-blocking antibodies are explored for metabolic diseases due to their potential to modulate lipid metabolism by inhibiting ANGPTL6-mediated suppression of lipoprotein lipase (LPL), a key enzyme in triglyceride clearance. Additionally, ANGPTL6's role in promoting angiogenesis has spurred interest in antibody-based strategies for cancer or retinopathy.
Current research focuses on optimizing antibody specificity, affinity, and delivery mechanisms. Challenges include understanding tissue-specific effects and minimizing off-target interactions. ANGPTL6 antibodies represent a promising but evolving area in metabolic and vascular disease therapeutics.
×
