| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | NGFI-A-binding protein 2, EGR-1-binding protein 2, Melanoma-associated delayed early response protein, Protein MADER, NAB2, MADER |
| Entrez GeneID | 4665 |
| WB Predicted band size | 56.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This NAB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 109-138 amino acids from the Central region of human NAB2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) . |
+ +
以下是关于NAB2抗体的3篇参考文献及其摘要概述：
---
1. **文献名称**: *NAB2-STAT6 Fusion Gene in Solitary Fibrous Tumor: Diagnostic Utility in Clinical Practice*
**作者**: Doyle LA, et al.
**摘要**: 该研究验证了NAB2抗体在免疫组化(IHC)中对NAB2-STAT6融合蛋白的特异性检测能力，证实其在孤立性纤维性肿瘤(SFT)诊断中的高敏感性和特异性，为病理鉴别提供可靠工具。
---
2. **文献名称**: *NAB2. a Transcriptional Corepressor of EGR1. Regulates Cell Proliferation and Cancer Pathways*
**作者**: Kim J, Andres V.
**摘要**: 通过Western blot和免疫荧光实验，研究揭示了NAB2作为早期生长反应蛋白(EGR1)的共抑制因子，调控细胞增殖和癌症相关通路的功能，并验证了NAB2抗体的特异性在体外模型中的应用。
---
3. **文献名称**: *Expression and Functional Analysis of NAB2 in Drosophila Neural Development*
**作者**: Kedmi A, et al.
**摘要**: 利用NAB2抗体定位果蝇中枢神经系统的蛋白表达，研究发现NAB2通过调控轴突导向分子参与神经发育，抗体特异性经敲除实验验证，为神经发育机制研究提供支持。
---
4. **文献名称**: *Utility of NAB2 Antibody in Differentiating Benign and Malignant Mesenchymal Tumors*
**作者**: Yamada Y, et al.
**摘要**: 评估NAB2抗体在区分良恶性间叶源性肿瘤中的价值，结合组织微阵列分析，证明其在肉瘤亚型鉴别中的潜在临床意义，强调抗体标准化检测流程的重要性。
---
以上文献均聚焦于NAB2抗体的应用场景(如诊断、功能研究)及其在疾病机制中的角色。如需具体期刊信息或年份，建议通过PubMed/Google Scholar按标题检索。
The NAB2 antibody is a tool used to detect the NAB2 (NGFI-A Binding Protein 2) protein, a transcriptional regulator involved in modulating gene expression. NAB2. encoded by the *NAB2* gene on chromosome 12q13.3. functions as a corepressor or coactivator depending on cellular context. It interacts with Early Growth Response (EGR) family transcription factors, particularly EGR1. to fine-tune their activity in processes like cell proliferation, differentiation, and apoptosis. Dysregulation of NAB2 is implicated in cancer, notably in soft tissue sarcomas. A hallmark is the *NAB2-STAT6* gene fusion, resulting from a chromosomal inversion, which is a diagnostic marker for solitary fibrous tumor (SFT) and hemangiopericytoma. This fusion generates an oncogenic protein that alters transcriptional programs, driving tumorigenesis.
NAB2 antibodies are critical in research and diagnostics, enabling the detection of wild-type NAB2 or the NAB2-STAT6 fusion protein via techniques like immunohistochemistry (IHC), Western blotting, or immunofluorescence. They aid in studying NAB2's role in chromatin remodeling, transcriptional repression, and its interplay with signaling pathways like TGF-β and MAPK. Commercially available monoclonal or polyclonal NAB2 antibodies are validated for specificity and sensitivity, supporting advancements in understanding tumor biology and developing targeted therapies.
×
