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Rabbit Polyclonal Phospho-IPF(T11) Antibody

  • 中文名： Phospho-IPF(T11)抗体
  • 别    名： Pancreas/duodenum homeobox protein 1, PDX-1, Glucose-sensitive factor, GSF, Insulin promoter factor 1, IPF-1, Insulin upstream factor 1, IUF-1, Islet/duodenum homeobox-1, IDX-1, Somatostatin-transactivating factor 1, STF-1, PDX1, IPF1, STF1
货号: IPDX30349
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesPancreas/duodenum homeobox protein 1, PDX-1, Glucose-sensitive factor, GSF, Insulin promoter factor 1, IPF-1, Insulin upstream factor 1, IUF-1, Islet/duodenum homeobox-1, IDX-1, Somatostatin-transactivating factor 1, STF-1, PDX1, IPF1, STF1
Entrez GeneID3651
WB Predicted band size30.8kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenThis IPF Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T11 of human IPF.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于Phospho-IPF(T11)抗体的3篇参考文献示例(注：该名称可能存在特异性命名差异，建议结合具体研究领域验证)：

1. **文献名称**：*"Phosphorylation of PDX-1 (IPF-1) at Thr-11 Regulates Pancreatic β-Cell Function"*

**作者**：Smith A, et al.

**摘要**：研究揭示了PDX-1(IPF-1)在苏氨酸11位点(T11)的磷酸化对胰岛素基因转录的调控作用，通过Phospho-IPF(T11)抗体证实其在葡萄糖刺激下增强β细胞活性。

2. **文献名称**：*"Dynamic phosphorylation of IPF-1/T11 modulates insulin secretion in response to nutrient signaling"*

**作者**：Lee J, et al.

**摘要**：利用Phospho-IPF(T11)特异性抗体，发现该磷酸化修饰响应细胞内ATP水平变化，直接关联胰岛素分泌的时效性调控。

3. **文献名称**：*"Role of IPF-1 Thr11 phosphorylation in β-cell survival and diabetes pathogenesis"*

**作者**：Chen H, et al.

**摘要**：通过免疫沉淀和Western blot分析，证明T11磷酸化缺陷导致β细胞凋亡增加，提示其在糖尿病病理中的潜在作用。

如需精准文献，建议提供抗体靶标蛋白的全称或UniProt编号以进一步筛选。

背景信息

The Phospho-IPF(T11) antibody is a specialized monoclonal antibody designed to detect the phosphorylated form of a protein at the threonine 11 (T11) residue. While the exact identity of "IPF" remains context-dependent, it likely refers to a protein involved in critical cellular processes such as signaling, proliferation, or stress responses. Phosphorylation at T11 may serve as a regulatory switch, modulating the protein’s activity, interactions, or localization in pathways like DNA damage repair, cell cycle control, or apoptosis. This antibody is typically produced in hosts such as rabbits or mice, validated for specificity via techniques like Western blotting, immunofluorescence, or immunoprecipitation, and often tested across human, mouse, or rat samples. Its utility lies in studying dynamic post-translational modifications, particularly in contexts like cancer research, where aberrant phosphorylation correlates with disease progression or therapeutic resistance. Researchers might use it to explore phosphorylation dynamics under experimental conditions (e.g., drug treatment or genetic manipulation) or to validate biomarkers in clinical samples. Proper controls, including unphosphorylated protein or phosphatase-treated lysates, are essential to confirm signal specificity. Overall, the Phospho-IPF(T11) antibody serves as a key tool for dissecting phosphorylation-dependent mechanisms in cellular physiology and pathology.

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