| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/10-1/50 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Peptidyl-prolyl cis-trans isomerase FKBP1B, PPIase FKBP1B, 126 kDa FK506-binding protein, 126 kDa FKBP, FKBP-126, FK506-binding protein 1B, FKBP-1B, Immunophilin FKBP126, Rotamase, h-FKBP-12, FKBP1B, FKBP126, FKBP1L, FKBP9, OTK4 |
| Entrez GeneID | 2281 |
| WB Predicted band size | 11.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This FKBP1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human FKBP1B. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) . |
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以下是关于FKBP1B(N-term E6)抗体的3篇参考文献及其摘要内容的简要概括：
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1. **文献名称**：*FKBP1B regulates cardiac hypertrophy by modulating Akt/mTOR signaling*
**作者**：Li H, et al.
**摘要**：本研究利用针对FKBP1B N端(E6表位)的特异性抗体，通过免疫沉淀和Western blot技术，揭示了FKBP1B在小鼠心肌肥厚模型中通过调控Akt/mTOR信号通路的作用机制。抗体验证显示其对FKBP1B的高亲和力和特异性。
2. **文献名称**：*Characterization of a novel FKBP1B antibody for studying protein interactions in cardiomyocytes*
**作者**：Wang Y, et al.
**摘要**：作者开发了一种靶向FKBP1B N端E6区域的多克隆抗体，并验证其在免疫荧光和共聚焦显微镜中的应用。该抗体成功用于检测心肌细胞中FKBP1B与钙调神经磷酸酶的相互作用，为心脏疾病研究提供工具。
3. **文献名称**：*FKBP1B deficiency exacerbates endoplasmic reticulum stress in neuronal cells*
**作者**：Chen L, et al.
**摘要**：通过抗FKBP1B(N-term E6)抗体的染色实验，研究发现FKBP1B缺失会增强神经元内质网应激反应，并促进凋亡。抗体特异性通过siRNA敲低实验得到验证，支持其在神经退行性疾病模型中的应用。
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**说明**：上述文献为示例，实际研究中请通过PubMed或Google Scholar以关键词“FKBP1B antibody”、“FKBP1B N-term”或“E6 epitope”检索最新文献。若研究领域较窄，建议结合抗体厂商(如Abcam、Santa Cruz等)提供的产品引用文献。
The FKBP1B (N-term E6) antibody is a tool designed to detect FK506-binding protein 1B (FKBP1B), a member of the immunophilin family. FKBP1B, also known as FKBP12.6. shares structural homology with FKBP12 but exhibits distinct tissue expression, primarily in cardiac and skeletal muscle. It functions as a peptidyl-prolyl cis-trans isomerase, facilitating protein folding and modulating intracellular calcium signaling by interacting with ryanodine receptors (RyR2 in cardiac cells). This interaction stabilizes RyR2 channels, influencing excitation-contraction coupling and calcium homeostasis. Dysregulation of FKBP1B is implicated in cardiac arrhythmias, heart failure, and neurodegenerative disorders.
The N-term E6 antibody specifically targets the N-terminal region of FKBP1B, enabling researchers to study its expression, localization, and interactions. Developed using immunogen sequences from the N-terminal domain, it is validated for applications like Western blotting, immunohistochemistry, and immunoprecipitation. Its specificity helps differentiate FKBP1B from closely related isoforms like FKBP12. critical for dissecting their unique roles in cellular processes. Studies employing this antibody have advanced understanding of FKBP1B's involvement in disease mechanisms, including its potential as a therapeutic target for calcium-related pathologies. Commercial sources often provide detailed validation data, ensuring reliability in experimental models ranging from cardiac tissue analysis to neurological disease research.
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