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Rabbit Polyclonal GOLPH3 Antibody

  • 中文名： GOLPH3抗体
  • 别    名： Golgi phosphoprotein 3, Coat protein GPP34, Mitochondrial DNA absence factor, MIDAS, GOLPH3, GPP34
货号: IPDX30342
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 1/10-1/50 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesGolgi phosphoprotein 3, Coat protein GPP34, Mitochondrial DNA absence factor, MIDAS, GOLPH3, GPP34
Entrez GeneID64083
WB Predicted band size33.8kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenThis GOLPH3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 251-279 amino acids from the C-terminal region of human GOLPH3.
FormulationPurified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) .

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参考文献

以下是关于GOLPH3抗体的3篇参考文献及其摘要概括：

1. **《GOLPH3 modulates mTOR signalling and rapamycin sensitivity in cancer》**

- **作者**：Scott, K. L., et al.

- **摘要**：该研究首次发现GOLPH3在多种癌症中过表达，并通过抗体检测(如Western blot和免疫组化)证实其与mTOR信号通路的关联，提示GOLPH3可能作为癌症治疗靶点。

2. **《Overexpression of GOLPH3 is associated with poor prognosis and clinical progression in gastric cancer》**

- **作者**：Zhou, J., et al.

- **摘要**：利用GOLPH3抗体对胃癌组织进行免疫组化分析，发现GOLPH3高表达与肿瘤分期、转移及患者生存率显著相关，表明其可作为胃癌预后标志物。

3. **《GOLPH3 promotes epithelial-mesenchymal transition via regulating integrin β1 in colorectal cancer》**

- **作者**：Kuniguchi, K., et al.

- **摘要**：通过抗体介导的蛋白表达检测，研究发现GOLPH3通过调控整合素β1促进结直肠癌上皮-间质转化(EMT)，揭示了其在肿瘤侵袭中的分子机制。

4. **《DNA damage triggers Golgi dispersal via GOLPH3 phosphorylation to enhance cell survival》**

- **作者**：Farber-Katz, S., et al.

- **摘要**：研究使用GOLPH3抗体观察DNA损伤后高尔基体结构变化，发现磷酸化GOLPH3介导高尔基体碎裂，从而影响细胞应激反应和存活能力。

这些文献均通过GOLPH3抗体进行蛋白定位、表达水平或功能研究，涵盖癌症机制、预后及治疗领域。

背景信息

GOLPH3 (Golgi Phosphoprotein 3) is a peripheral membrane protein localized to the Golgi apparatus, involved in maintaining Golgi structure, vesicular trafficking, and cellular stress responses. Discovered in 2008. GOLPH3 gained attention as a potential oncogene due to its amplification in multiple cancers, including melanoma, breast, lung, and colorectal cancers. Overexpression of GOLPH3 is linked to enhanced mTOR signaling, uncontrolled cell proliferation, and poor prognosis. Antibodies targeting GOLPH3 are essential tools for studying its expression, localization, and functional roles in cancer biology. These antibodies are widely used in techniques like immunohistochemistry (IHC), immunofluorescence (IF), and Western blotting (WB) to assess GOLPH3 levels in tissue samples or cell lines. Research using GOLPH3 antibodies has contributed to understanding its interaction with components of the secretory pathway and its role in promoting tumor growth and chemotherapy resistance. Developing specific and reliable GOLPH3 antibodies remains critical for both diagnostic applications (e.g., cancer biomarker detection) and therapeutic exploration, such as evaluating GOLPH3-targeted therapies in preclinical models. Validation of these antibodies ensures specificity across species and experimental conditions, supporting translational cancer research.

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