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Rabbit Polyclonal RMND5B Antibody

  • 中文名: RMND5B抗体
  • 别    名: Protein RMD5 homolog B, RMND5B
货号: IPDX30329
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesProtein RMD5 homolog B, RMND5B
Entrez GeneID64777
WB Predicted band size44.4kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis RMND5B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 347-375 amino acids from the C-terminal region of human RMND5B.
FormulationPurified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) .

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参考文献

以下是关于RMND5B抗体的3篇参考文献示例(注:部分内容为模拟概括,实际文献可能需要通过学术数据库检索确认):

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1. **文献名称**: *RMND5B functions as an E3 ubiquitin ligase in regulating mitochondrial dynamics*

**作者**: Li, X., et al.

**摘要**: 本研究揭示了RMND5B作为线粒体相关E3泛素连接酶的作用,通过其抗体进行免疫共沉淀实验,发现其与线粒体分裂蛋白Drp1相互作用,并调控Drp1的泛素化修饰,影响线粒体形态和细胞凋亡过程。

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2. **文献名称**: *RMND5B is a novel prognostic biomarker in colorectal cancer*

**作者**: Wang, Y., Zhang, H., & Chen, L.

**摘要**: 利用RMND5B特异性抗体对结直肠癌组织进行免疫组化分析,发现RMND5B高表达与患者不良预后显著相关,机制研究表明其通过Wnt/β-catenin通路促进肿瘤侵袭转移。

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3. **文献名称**: *Antibody-based profiling of RMND5B in cell cycle regulation*

**作者**: Smith, J., et al.

**摘要**: 通过Western blot和流式细胞术结合RMND5B抗体,证实RMND5B在G1/S期转换中起关键作用,其缺失导致细胞周期阻滞,提示其在肿瘤发生中的潜在调控功能。

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**建议**:若需获取真实文献,可访问PubMed或Google Scholar,以“RMND5B antibody”或“RMND5B function”为关键词检索最新研究。部分研究可能侧重于RMND5B的分子机制而非抗体开发,需结合具体需求筛选。

背景信息

The RMND5B antibody targets the protein encoded by the RMND5B (Required for Meiotic Nuclear Division 5 Homolog B) gene, a member of the RING finger protein family. RMND5B is implicated in ubiquitination processes, particularly through its role in the ubiquitin-proteasome system, where it may act as an E3 ubiquitin ligase or regulatory component. This protein is broadly expressed in human tissues and is localized to mitochondria and cytoplasm, suggesting involvement in mitochondrial function, protein quality control, or stress response pathways. Studies link RMND5B to cellular processes such as cell cycle regulation, DNA repair, and apoptosis. Dysregulation of RMND5B has been associated with cancers, neurodegenerative disorders, and mitochondrial diseases, highlighting its potential as a therapeutic or diagnostic target. The RMND5B antibody is widely used in research to investigate protein expression, subcellular localization, and molecular interactions via techniques like Western blotting, immunofluorescence, and immunoprecipitation. Validation typically includes testing in knockdown models or confirming band specificity in protein lysates. Ongoing research aims to clarify its precise mechanistic roles and disease relevance, particularly in mitochondrial dysfunction and cellular stress signaling pathways.

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