| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Protein kinase C delta-binding protein, Cavin-3, Serum deprivation response factor-related gene product that binds to C-kinase, hSRBC, PRKCDBP, SRBC |
| Entrez GeneID | 112464 |
| WB Predicted band size | 27.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This PRKCDBP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 113-144 amino acids from the Central region of human PRKCDBP. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) . |
+ +
以下是关于PRKCDBP(Protein Kinase C Delta Binding Protein，也称SPIN90)抗体的示例参考文献(内容为假设性示例，实际文献需通过学术数据库验证)：
---
1. **标题**：*SPIN90/PKCDBP regulates cell migration via interaction with protein kinase Cδ*
**作者**：Lee JH, Kim HS, Park SH (2005)
**摘要**：本研究揭示了PRKCDBP(SPIN90)与PKCδ的相互作用在细胞迁移中的关键作用。通过特异性抗体阻断实验，发现PRKCDBP通过调控PKCδ的磷酸化水平影响细胞骨架重组，为肿瘤转移机制提供了新见解。
2. **标题**：*PRKCDBP expression correlates with glioblastoma progression and survival*
**作者**：Chen L, Wang Y, Zhang R (2012)
**摘要**：利用PRKCDBP抗体对胶质母细胞瘤组织进行免疫组化分析，发现高表达PRKCDBP与患者生存率降低显著相关，提示其可作为潜在预后标志物及治疗靶点。
3. **标题**：*PRKCDBP modulates autophagy in cancer cells through mTOR signaling*
**作者**：Sato K, Tanaka M (2018)
**摘要**：通过Western blot和免疫荧光(使用PRKCDBP抗体)证实，PRKCDBP通过抑制mTOR通路促进癌细胞自噬，为靶向自噬的抗癌策略提供了实验依据。
4. **标题**：*A review: The dual role of PRKCDBP in tumorigenesis and immune regulation*
**作者**：Gupta S, Patel T (2021)
**摘要**：综述总结了PRKCDBP在癌症中的促瘤/抑瘤双重功能，重点讨论了基于抗体的检测方法在临床研究中的应用及其与肿瘤微环境的关联。
---
**建议**：
- 实际文献可通过PubMed或Google Scholar搜索关键词：**PRKCDBP antibody**、**SPIN90 antibody**、**PKCδ binding protein**。
- 关注功能研究(如信号通路、疾病机制)或抗体应用(如Western blot、IHC)的论文。
The PRKCDBP (Protein Kinase C Delta Binding Protein) antibody is a tool used to detect and study the PRKCDBP protein, also known as SRCIN1 or SPIN90. PRKCDBP is a scaffold protein that interacts with Protein Kinase C delta (PKCδ), a serine/threonine kinase involved in diverse cellular processes, including apoptosis, differentiation, and immune responses. PRKCDBP regulates PKCδ activity by facilitating its localization, stability, and interaction with downstream signaling partners. It plays a critical role in cytoskeletal reorganization, cell migration, and cancer progression, particularly in tumors like lung and breast cancer.
Antibodies targeting PRKCDBP are widely used in research to investigate its expression patterns, subcellular distribution, and functional mechanisms. They are applied in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to explore PRKCDBP's role in signaling pathways, tumor metastasis, and therapeutic resistance. Studies have linked PRKCDBP dysregulation to neurodegenerative diseases and immune disorders, highlighting its broader biomedical relevance.
Validation of PRKCDBP antibodies often involves knockout cell lines or siRNA-mediated silencing to confirm specificity. These reagents are essential for advancing understanding of PKCδ-mediated signaling and developing potential diagnostic or therapeutic strategies targeting this pathway.
×
