| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Mitochondrial intermediate peptidase, MIP, MIPEP, MIP |
| Entrez GeneID | 4285 |
| WB Predicted band size | 80.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This MIPEP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 307-336 amino acids from the Central region of human MIPEP. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) . |
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以下是关于MIPEP抗体的示例参考文献(模拟内容，建议通过学术数据库核实)：
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1. **文献名称**: *Mitochondrial Intermediate Peptidase (MIPEP) in Neurodegenerative Disorders*
**作者**: Smith A, et al.
**摘要**: 本研究使用MIPEP特异性抗体，通过Western blot和免疫荧光技术，发现MIPEP在阿尔茨海默病患者脑组织中线粒体功能异常相关，提示其可能参与神经退行性病变的调控机制。
2. **文献名称**: *Characterization of MIPEP Antibody for Mitochondrial Protein Processing Studies*
**作者**: Lee B, et al.
**摘要**: 报道了一种新型MIPEP多克隆抗体的开发与验证，证明其在线粒体提取物中特异性识别并检测MIPEP蛋白，为研究线粒体前体蛋白的加工机制提供了工具。
3. **文献名称**: *MIPEP Expression Correlates with Cancer Metabolic Reprogramming*
**作者**: Chen X, et al.
**摘要**: 通过免疫组化分析发现，MIPEP在多种癌症组织中高表达，且其表达水平与肿瘤细胞线粒体代谢活性呈正相关，提示其可能作为癌症治疗的潜在靶点。
4. **文献名称**: *Functional Analysis of MIPEP Knockout Models Using Antibody-Based Validation*
**作者**: Tanaka K, et al.
**摘要**: 利用MIPEP抗体验证基因敲除小鼠模型，发现MIPEP缺失导致线粒体肽段积累，进而影响心脏和肌肉组织的能量代谢功能。
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**注意**：以上为模拟示例，实际文献需通过PubMed、Google Scholar等平台检索关键词(如“MIPEP antibody”、“mitochondrial peptidase”)获取。
The MIPEP antibody targets the mitochondrial intermediate peptidase (MIPEP), a metalloprotease encoded by the *MIPEP* gene. MIPEP, also known as HMIP or MIP, plays a critical role in processing nuclear-encoded precursor proteins imported into the mitochondrial matrix. It cleaves an octapeptide from the N-terminus of precursor proteins after their initial processing by mitochondrial processing peptidase (MPP), facilitating their maturation into functional forms. This step is essential for maintaining mitochondrial proteostasis and metabolic functions, particularly in energy production pathways.
MIPEP is implicated in several cellular processes, including oxidative phosphorylation, amino acid metabolism, and apoptosis. Dysregulation of MIPEP has been linked to mitochondrial disorders, neurodegenerative diseases, and cancers. For instance, mutations in *MIPEP* are associated with early-onset mitochondrial encephalopathy and cardiomyopathy. Antibodies against MIPEP are widely used in research to study its expression, localization, and role in mitochondrial protein processing. They enable detection via techniques like Western blotting, immunohistochemistry, and immunofluorescence, aiding investigations into mitochondrial dysfunction mechanisms.
Commercial MIPEP antibodies are typically raised in rabbits or mice using synthetic peptides or recombinant protein fragments. Validation includes testing in knockout cell lines or tissues to ensure specificity. These tools are vital for exploring MIPEP's diagnostic or therapeutic potential in diseases linked to mitochondrial impairment.
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