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Rabbit Polyclonal Phospho-TERT(S1125) Antibody

  • 中文名： Phospho-TERT(S1125)抗体
  • 别    名： Telomerase reverse transcriptase, HEST2, Telomerase catalytic subunit, Telomerase-associated protein 2, TP2, TERT, EST2, TCS1, TRT
货号: IPDX30278
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesTelomerase reverse transcriptase, HEST2, Telomerase catalytic subunit, Telomerase-associated protein 2, TP2, TERT, EST2, TCS1, TRT
Entrez GeneID7015
WB Predicted band size127.0kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis TERT Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S1125 of human TERT.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于Phospho-TERT(S1125)抗体的示例参考文献(注：以下内容为模拟示例，实际文献需通过学术数据库验证)：

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1. **文献名称**: "Phosphorylation of TERT at Serine 1125 Modulates Telomerase Activity in Cancer Cells"

**作者**: Kang, S. et al.

**摘要**: 本研究揭示了TERT在S1125位点的磷酸化通过AKT激酶调控端粒酶活性。作者使用Phospho-TERT(S1125)特异性抗体，证明该修饰在多种癌症细胞系中与端粒延长和细胞增殖相关。

2. **文献名称**: "A Novel Phospho-Specific Antibody for TERT Ser1125 in DNA Damage Response"

**作者**: Liu, Y. et al.

**摘要**: 开发了一种高特异性Phospho-TERT(S1125)抗体，并验证其在DNA损伤条件下的应用。研究发现，S1125磷酸化在ATM/ATR信号通路中响应氧化应激，影响端粒稳定性。

3. **文献名称**: "Role of TERT S1125 Phosphorylation in Epithelial-Mesenchymal Transition"

**作者**: Zhang, R. et al.

**摘要**: 通过免疫沉淀和Western blot分析(使用Phospho-TERT(S1125)抗体)，证实S1125磷酸化促进TERT的核转位，增强肿瘤细胞的侵袭性和转移能力。

4. **文献名称**: "Validation of a Commercial Phospho-TERT(S1125) Antibody for Clinical Biomarker Studies"

**作者**: Smith, J. & Patel, K.

**摘要**: 评估了市售Phospho-TERT(S1125)抗体的灵敏度和特异性，证明其在乳腺癌组织样本中可作为预后标志物，与患者生存率显著相关。

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**建议**：实际文献可通过PubMed、Google Scholar等平台，以关键词“Phospho-TERT Ser1125”“TERT phosphorylation antibody”检索。部分抗体厂商(如Cell Signaling Technology、Abcam)的技术文档也可能提供相关参考文献。

背景信息

The Phospho-TERT(S1125) antibody is a specialized tool used to detect the phosphorylation of human telomerase reverse transcriptase (TERT) at serine residue 1125. TERT, the catalytic subunit of telomerase, plays a critical role in maintaining telomere length by adding repetitive DNA sequences to chromosome ends, thereby promoting cellular proliferation and survival. Post-translational modifications, such as phosphorylation, regulate TERT activity, localization, and interactions with other proteins. The S1125 phosphorylation site, located in the C-terminal domain of TERT, is implicated in modulating telomerase function and subcellular trafficking. Studies suggest that phosphorylation at this residue may influence TERT’s nuclear import or stability, potentially affecting its role in aging, cancer, and stem cell biology. This antibody is commonly employed in Western blotting, immunofluorescence, or immunohistochemistry to investigate TERT regulation in contexts like oncogenesis, where telomerase is frequently reactivated. Researchers use it to explore signaling pathways (e.g., AKT or PKC kinases) that phosphorylate TERT, offering insights into therapeutic strategies targeting telomerase in cancers. Validation typically includes testing in cell lines with known TERT expression or phosphorylation status. Proper controls, such as dephosphorylation treatments or mutation-based assays, are essential to confirm specificity.

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