| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Protein angel homolog 2, ANGEL2, KIAA0759L |
| Entrez GeneID | 90806 |
| WB Predicted band size | 62.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ANGEL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 108-138 amino acids from the Central region of human ANGEL2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) . |
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以下是关于ANGEL2抗体的示例性参考文献(注：部分内容为示例性概括，实际文献需通过学术数据库核实)：
1. **"ANGEL2 is a member of the tRNA splicing complex critical for embryonic development and survival"**
*作者：Nakamura et al.*
**摘要**：研究发现ANGEL2作为tRNA剪切复合物的组成部分，通过基因敲除小鼠模型结合抗体免疫沉淀技术，揭示其在胚胎发育中的必要性，并参与维持细胞稳态。
2. **"ANGEL2 regulates pancreatic β-cell function by modulating stress granule dynamics"**
*作者：Zhang et al.*
**摘要**：利用ANGEL2特异性抗体进行免疫荧光和Western blot，发现其在胰岛β细胞中通过调控应激颗粒形成影响胰岛素分泌，为糖尿病机制提供新见解。
3. **"A novel ANGEL2 monoclonal antibody reveals its overexpression in colorectal cancer progression"**
*作者：Wang et al.*
**摘要**：开发了一种高特异性ANGEL2单克隆抗体，应用于结直肠癌组织芯片分析，发现ANGEL2表达与肿瘤转移和患者预后显著相关。
4. **"ANGEL2 interacts with the RNA exosome to process ribosomal RNAs"**
*作者：Köhler et al.*
**摘要**：通过抗体共免疫沉淀和质谱分析，证明ANGEL2与RNA外泌体复合物互作，参与核糖体RNA加工，维持细胞转录组稳定性。
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**注意**：以上为基于领域知识的模拟文献，实际研究需通过PubMed、Google Scholar等平台以关键词“ANGEL2 antibody”“ANGEL2 function”检索。真实文献可能涉及结构解析、疾病关联或技术应用等方向。
The ANGEL2 (ANGEL homolog 2) antibody is a tool used to study the ANGEL2 protein, a member of the conserved ANGEL (anchor gene expression and lipid metabolism) protein family. ANGEL2 is implicated in RNA processing and mitochondrial function, with roles in regulating translation and cellular stress responses. It shares structural homology with the yeast protein Hbs1. which is involved in ribosome-associated quality control. Research suggests ANGEL2 interacts with the CCR4-NOT complex, a key regulator of mRNA stability and degradation, linking it to post-transcriptional gene expression.
The ANGEL2 antibody enables detection and localization of the protein in various experimental models, such as Western blotting, immunofluorescence, and immunohistochemistry. Studies using this antibody have explored ANGEL2's involvement in developmental processes, metabolic homeostasis, and diseases like cancer or neurodegenerative disorders. For instance, ANGEL2 dysregulation has been observed in certain cancers, potentially influencing tumor progression via RNA metabolism pathways.
Developed in hosts like rabbits or mice, ANGEL2 antibodies are often validated through knockout/knockdown controls to ensure specificity. Their applications span basic research on RNA biology, mitochondrial dynamics, and translational control, as well as clinical investigations into disease biomarkers. The antibody's utility underscores ANGEL2's emerging significance in cellular adaptation mechanisms and pathology.
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