| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 1/10-1/50 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Hepatoma-derived growth factor, HDGF, High mobility group protein 1-like 2, HMG-1L2, HDGF, HMG1L2 |
| Entrez GeneID | 3068 |
| WB Predicted band size | 26.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This HDGF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 171-197 amino acids from the C-terminal region of human HDGF. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) . |
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以下是3篇涉及HDGF抗体的研究文献摘要概览：
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1. **"Hepatoma-derived growth factor promotes cell proliferation, migration, and invasion in ovarian cancer"**
*作者：Zhang Y, et al.*
摘要：本研究利用HDGF抗体检测卵巢癌组织中HDGF蛋白表达，发现其高表达与肿瘤增殖、转移及不良预后相关。体外实验显示HDGF抗体可部分抑制癌细胞侵袭能力，提示HDGF可能成为治疗靶点。
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2. **"HDGF as a prognostic biomarker in non-small cell lung cancer: Immunohistochemical analysis"**
*作者：Liu X, et al.*
摘要：通过免疫组化(使用HDGF特异性抗体)分析非小细胞肺癌样本，证实HDGF高表达与患者生存期缩短及淋巴结转移显著相关，表明其可作为潜在预后标志物。
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3. **"Antibody-mediated targeting of HDGF suppresses tumor angiogenesis in colorectal cancer models"**
*作者：Chen H, et al.*
摘要：研究开发了一种中和性HDGF单克隆抗体，在结直肠癌小鼠模型中验证其抑制肿瘤血管生成的效果，证实抗体通过阻断HDGF与内皮细胞相互作用降低微血管密度，减缓肿瘤生长。
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*注：以上为模拟摘要，实际文献需通过学术数据库(如PubMed)检索确认。如需具体文章，可提供更详细的研究方向或年份要求。*
**Background of HDGF Antibody**
Hepatoma-derived growth factor (HDGF) is a secreted protein initially identified in hepatocellular carcinoma. It plays roles in cell proliferation, differentiation, angiogenesis, and tumorigenesis. HDGF interacts with DNA, heparin, and other proteins via its N-terminal PWWP domain, regulating gene expression and signaling pathways such as PI3K/AKT and Wnt. Overexpression of HDGF is linked to poor prognosis in cancers, including lung, breast, and liver cancers, highlighting its oncogenic role.
HDGF antibodies are critical tools for detecting HDGF expression in research and diagnostics. They enable techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study HDGF localization and levels in tissues or cell lines. These antibodies help elucidate HDGF's involvement in cancer progression, metastasis, and resistance to therapy. Recent studies also explore HDGF as a potential therapeutic target, with antibodies being used to block its function or deliver targeted therapies.
Additionally, HDGF antibodies aid in understanding its non-cancer roles, such as in vascular development and tissue repair. Their specificity and validation are crucial for accurate experimental outcomes, driving advancements in both basic research and clinical applications.
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