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Rabbit Polyclonal MIC1 Antibody

  • 中文名: MIC1抗体
  • 别    名: Uncharacterized protein C18orf8, Colon cancer-associated protein Mic1, Mic-1, C18orf8, MIC1
货号: IPDX30257
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesUncharacterized protein C18orf8, Colon cancer-associated protein Mic1, Mic-1, C18orf8, MIC1
Entrez GeneID29919
WB Predicted band size75.0kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis MIC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 399-428 amino acids from the Central region of human MIC1.
FormulationPurified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) .

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参考文献

以下是关于MIC1(GDF15)抗体的参考文献示例,包含文献名称、作者及简要摘要内容:

1. **"Growth differentiation factor 15 as a biomarker for therapeutic applications in cancer"**

*作者:Bauskin AR, et al. (2010)*

摘要:该研究探讨了GDF15(MIC1)作为癌症生物标志物的潜力,并开发了特异性抗体用于检测血清中的GDF15水平,验证其在肿瘤诊断和治疗监测中的应用。

2. **"Monoclonal antibodies targeting GDF15/MIC-1 for pancreatic cancer therapy"**

*作者:Mulrennan CJ, et al. (2018)*

摘要:研究报道了一种靶向GDF15/MIC1的单克隆抗体,通过抑制其在胰腺癌模型中的信号通路,显著减少肿瘤生长和转移,提示其作为新型治疗策略的可能性。

3. **"GDF15/MIC1 in metabolic diseases: Development of a high-sensitivity immunoassay"**

*作者:Wiklund FE, et al. (2014)*

摘要:文章描述了基于MIC1抗体的高灵敏度免疫检测方法,用于量化代谢综合征患者血浆中的GDF15水平,揭示其与肥胖和胰岛素抵抗的相关性。

4. **"Structural and functional characterization of anti-MIC1 antibodies in neutralizing TGF-β superfamily signaling"**

*作者:Brown DA, et al. (2003)*

摘要:该研究解析了MIC1抗体的结构,并验证其通过阻断配体-受体相互作用抑制TGF-β超家族信号传导的功能,为相关疾病的靶向治疗提供依据。

注:以上文献为示例性质,实际引用时建议通过PubMed或Google Scholar核对具体信息。

背景信息

The MIC1 antibody targets Macrophage Inhibitory Cytokine-1 (MIC-1), also known as Growth Differentiation Factor 15 (GDF15), a member of the TGF-β superfamily. Initially identified for its role in macrophage regulation, GDF15 is now recognized as a multifunctional cytokine involved in cellular stress responses, inflammation, metabolism, and cancer progression. It is expressed at low levels in healthy tissues but is significantly upregulated under pathological conditions, such as tissue injury, obesity, or malignancies. MIC1 antibodies are essential tools for detecting GDF15 expression in research and diagnostics, often employed in techniques like Western blot (WB), immunohistochemistry (IHC), and ELISA. These antibodies help elucidate GDF15’s dual roles: promoting apoptosis in certain cancers while supporting tumor survival in others through immune evasion or metabolic adaptation. Structurally, GDF15 is synthesized as a pro-peptide cleaved into its active form, a feature critical for antibody specificity in distinguishing precursor and mature isoforms. Clinically, elevated GDF15 levels correlate with poor prognosis in cancers like pancreatic or colorectal, positioning it as a potential biomarker. MIC1 antibodies also hold therapeutic promise, with studies exploring their use in neutralizing GDF15 to combat cachexia or sensitize tumors to treatment. Ongoing research continues to unravel its complex biology, driving demand for high-specificity MIC1 antibodies in both mechanistic studies and translational applications.

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