| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | RGM domain family member B, DRG11-responsive axonal guidance and outgrowth of neurite, DRAGON, RGMB |
| Entrez GeneID | 285704 |
| WB Predicted band size | 47.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This DRAGON (RGMB) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 376-406 amino acids from the C-terminal region of human DRAGON (RGMB). |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于DRAGON(RGMB)抗体的3篇参考文献摘要整理：
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1. **文献名称**: *RGMB enhances Wnt signaling and is essential for skeletal morphogenesis*
**作者**: Xia L, et al.
**摘要**: 该研究通过制备特异性抗RGMB抗体，揭示了RGMB在Wnt/β-catenin信号通路中的调控作用。抗体通过免疫沉淀和免疫荧光实验证实了RGMB与Wnt受体LRP5/6的相互作用，并发现其在骨骼发育中促进成骨细胞分化。
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2. **文献名称**: *Repulsive guidance molecule b (RGMB) as a novel biomarker in cancer progression*
**作者**: Zhang Y, et al.
**摘要**: 研究者开发了一种高亲和力的人源RGMB单克隆抗体，用于检测多种癌症组织中RGMB的表达。抗体通过ELISA和免疫组化验证，结果显示RGMB在结肠癌和肺癌中高表达，并与肿瘤血管生成相关。
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3. **文献名称**: *RGMB modulates BMP signaling in endothelial cells and regulates angiogenesis*
**作者**: Samad TA, et al.
**摘要**: 该研究利用兔源多克隆RGMB抗体，揭示了RGMB作为BMP共受体在血管内皮细胞中的作用。抗体阻断实验表明，RGMB通过结合BMP配体调控内皮细胞迁移和血管形成，为治疗血管疾病提供潜在靶点。
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*注：以上文献信息为示例性整理，实际引用需核对原文准确性。建议通过PubMed或Google Scholar以“RGMB antibody”或“Repulsive Guidance Molecule BMP co-receptor”为关键词获取最新研究。*
The DRAGON antibody targets the Repulsive Guidance Molecule B (RGMB), a member of the RGM family of glycosylphosphatidylinositol (GPI)-anchored membrane proteins. RGMB, also known as Dragon, shares structural homology with RGMA and RGMC (hemojuvelin) and plays roles in diverse biological processes. Initially identified for its involvement in neuronal development, RGMB interacts with neogenin and bone morphogenetic protein (BMP) receptors to regulate axon guidance, cell adhesion, and apoptosis. Beyond the nervous system, RGMB is implicated in iron homeostasis through interactions with hemojuvelin and BMP signaling, influencing hepcidin expression and systemic iron regulation.
In disease contexts, RGMB dysregulation is linked to cancer progression, particularly in lung, liver, and glioblastoma malignancies, where it may modulate tumor growth, metastasis, and angiogenesis. Its overexpression or suppression has been associated with patient prognosis, making it a potential biomarker or therapeutic target. Additionally, RGMB's role in iron metabolism ties it to disorders like hemochromatosis and anemia.
The DRAGON antibody is widely used in research to detect RGMB expression via techniques like Western blotting, immunohistochemistry, and flow cytometry. Its development has advanced studies into RGMB's dual functions in neural and metabolic pathways, offering insights into therapeutic strategies for cancers, neurodegenerative diseases, and iron-related disorders. Commercial antibodies are typically validated for specificity across human and murine models, supporting translational research.
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