| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Transcription factor SOX-30, SOX30 |
| Entrez GeneID | 11063 |
| WB Predicted band size | 81.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This SOX30 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 373-403 amino acids from the Central region of human SOX30. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) . |
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以下是关于SOX30抗体的3篇参考文献示例(内容基于真实研究背景，但具体文献信息为虚构示例)：
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1. **文献名称**: *SOX30 regulates spermatogenesis through transcriptional activation of testis-specific genes*
**作者**: Li X, Wang Y, et al.
**摘要**: 本研究利用兔源SOX30多克隆抗体，通过染色质免疫沉淀(ChIP)和Western blot技术，揭示了SOX30在精子发生过程中通过直接结合靶基因启动子(如Tnp1、Prm2)调控其转录的机制。实验表明，SOX30缺失导致小鼠精子形成缺陷和不育。
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2. **文献名称**: *SOX30 expression is downregulated in lung adenocarcinoma and correlates with poor prognosis*
**作者**: Chen J, Zhang H, et al.
**摘要**: 通过免疫组化(IHC)结合抗人SOX30单克隆抗体，分析肺癌组织样本发现SOX30在肺腺癌中表达显著降低，且低表达与患者生存率下降相关。体外实验证实SOX30过表达抑制肿瘤细胞增殖和迁移。
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3. **文献名称**: *Developmental stage-specific expression of SOX30 in mouse testis revealed by antibody-based profiling*
**作者**: Kumar R, Gupta S, et al.
**摘要**: 使用小鼠SOX30特异性抗体进行组织免疫荧光分析，发现SOX30在青春期后睾丸生殖细胞中高表达，且定位在细胞核内。研究提示SOX30可能参与减数分裂后精细胞的成熟过程。
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注：以上文献信息为模拟示例，实际研究中建议通过PubMed或Google Scholar以“SOX30 antibody”及“SOX30 function”为关键词检索最新文献。
The SOX30 antibody is a research tool designed to detect the SOX30 protein, a member of the SOX (SRY-related HMG-box) transcription factor family. SOX proteins play critical roles in developmental processes, including cell differentiation, organogenesis, and tissue homeostasis. SOX30. encoded by the *SOX30* gene, is distinguished by its unique structure, containing a conserved HMG (High Mobility Group) DNA-binding domain and a C-terminal transactivation domain. Initially identified as a testis-specific protein, SOX30 is now recognized for its broader expression in tissues like the lung and brain, though its functional roles remain less characterized compared to other SOX members.
Research highlights SOX30's involvement in spermatogenesis, where it regulates germ cell maturation and meiosis. Knockout studies in mice reveal its essentiality for male fertility. Emerging evidence also links SOX30 to cancer, with downregulation observed in lung adenocarcinoma and testicular germ cell tumors, suggesting tumor-suppressive potential. Additionally, SOX30 may influence immune responses by modulating T-cell differentiation.
SOX30 antibodies, typically raised in rabbits or mice, enable detection via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Their specificity is validated using knockout controls or siRNA-mediated silencing. These antibodies are vital for exploring SOX30's biological mechanisms, clinical associations, and potential as a diagnostic or therapeutic target. Despite progress, further studies are needed to fully elucidate its regulatory networks and pathophysiological relevance.
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