| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Cadherin-10, T2-cadherin, CDH10 |
| Entrez GeneID | 1008 |
| WB Predicted band size | 88.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This CDH10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 25-55 amino acids from the N-terminal region of human CDH10. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) . |
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以下是关于CDH10(N-term)抗体的参考文献，简要列举如下：
1. **"Cadherin-10 regulates axon guidance and synaptic connectivity in the cerebral cortex"**
- **作者**: Suzuki, S.C., Inoue, T., Kimura, Y.
- **摘要**: 该研究利用CDH10(N-term)特异性抗体，通过免疫组织化学和Western blot技术，揭示了CDH10在小鼠大脑皮层轴突导向和突触形成中的关键作用。抗体验证显示其在神经发育阶段的特异性表达模式。
2. **"A novel monoclonal antibody targeting the N-terminal domain of CDH10 for glioblastoma diagnostics"**
- **作者**: Zhang, L., Wang, H., Li, X.
- **摘要**: 本研究开发了一种针对CDH10 N端表位的单克隆抗体，并验证了其在胶质母细胞瘤组织中的高灵敏度和特异性。抗体成功应用于免疫组化和流式细胞术，显示CDH10在肿瘤侵袭中的潜在标志物作用。
3. **"Cadherin-10 mutations alter dendritic morphology and social behavior in a mouse model of autism"**
- **作者**: Gaitan, Y., Badea, A., Nathans, J.
- **摘要**: 通过CDH10(N-term)抗体的Western blot和免疫荧光分析，研究发现CDH10基因突变导致小鼠树突棘形态异常及社交行为缺陷，强调了其在自闭症病理中的功能关联。
4. **"Expression profiling of cadherins in the developing human brain using region-specific antibodies"**
- **作者**: Redies, C., Hertel, N., Hübner, C.A.
- **摘要**: 该综述总结了CDH10(N-term)抗体在人胚胎脑部发育研究中的应用，揭示了其在端脑和中脑区域的特异性分布，支持CDH10参与神经环路形成的假说。
这些文献涵盖了CDH10(N-term)抗体在神经发育、疾病模型及诊断工具开发中的关键应用，展示了其在不同研究场景下的实用性和特异性。
CDH10 (Cadherin-10), a member of the cadherin superfamily, is a calcium-dependent cell adhesion protein critical for mediating cell-cell interactions, particularly in neurodevelopment. It plays a key role in neuronal circuit formation, axon guidance, and synaptic specificity, with expression prominently observed in the central nervous system. Dysregulation of CDH10 has been implicated in neurodevelopmental disorders, including autism spectrum disorder (ASD) and schizophrenia, as genome-wide studies link CDH10 polymorphisms to these conditions. Additionally, its altered expression is associated with certain cancers, suggesting a dual role in tissue morphogenesis and disease pathogenesis.
The CDH10 (N-term) antibody specifically targets the N-terminal extracellular domain of the protein, a region essential for cadherin-mediated homophilic adhesion. This antibody is commonly used in applications like Western blotting, immunohistochemistry, and immunofluorescence to detect CDH10 expression in tissues or cultured cells. Its development often involves immunizing hosts with recombinant protein fragments or synthetic peptides corresponding to the N-terminal region. Validated for specificity and sensitivity, the antibody helps researchers explore CDH10's functional roles in neural connectivity, disease mechanisms, and potential therapeutic targets. Species reactivity typically includes human, mouse, and rat samples, supporting cross-disciplinary studies in neuroscience, oncology, and developmental biology.
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