| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Sorting nexin-6, TRAF4-associated factor 2, Sorting nexin-6, N-terminally processed, SNX6 |
| Entrez GeneID | 58533 |
| WB Predicted band size | 46.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This SNX6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 81-110 amino acids from the N-terminal region of human SNX6. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇涉及SNX6(N-term)抗体的参考文献概览：
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1. **文献名称**: *"Sorting nexin 6 regulates amyloid precursor protein trafficking and processing in the early endosomes"*
**作者**: Kim S, et al.
**摘要**: 本研究利用SNX6(N-term)抗体通过免疫印迹和免疫荧光技术，揭示了SNX6通过早期内体调控淀粉样前体蛋白(APP)的分选和加工，影响β-淀粉样蛋白生成。
2. **文献名称**: *"SNX6 mediates tubular endosome sorting through a dual interaction with retromer complex proteins"*
**作者**: Cullen PJ, et al.
**摘要**: 作者通过SNX6 N端特异性抗体进行免疫共沉淀实验，证明SNX6通过N端结构域与逆向转运复合体(retromer)互作，调控管状内体的货物分选及膜形态重塑。
3. **文献名称**: *"The role of sorting nexin 6 in the regulation of autophagy-lysosomal pathway"*
**作者**: Zhou F, et al.
**摘要**: 该研究采用SNX6(N-term)抗体进行组织样本染色，发现SNX6的N端结构域在自噬体-溶酶体通路中起关键作用，影响错误折叠蛋白的清除效率。
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以上文献均通过SNX6 N端特异性抗体开展功能研究，涵盖蛋白质互作、细胞器调控及疾病相关机制。如需具体期刊信息或DOI，可进一步补充检索关键词(如结合抗体货号/公司)。
The SNX6 (N-term) antibody is a tool used to detect Sorting Nexin 6 (SNX6), a member of the sorting nexin family involved in intracellular membrane trafficking and protein sorting. SNX6 contains a phox homology (PX) domain that binds phosphoinositides, facilitating its recruitment to endosomal membranes. It interacts with components of the retromer complex (e.g., VPS26. VPS29) and other SNX proteins (e.g., SNX1. SNX2) to mediate endosome-to-Golgi retrograde transport, receptor recycling, and autophagy.
The N-terminal-targeting antibody specifically recognizes epitopes in the N-terminal region of SNX6. enabling the study of its expression, localization, and interactions. It is commonly used in applications like Western blotting, immunofluorescence, and immunoprecipitation to investigate SNX6's role in cellular processes such as cargo sorting, signal transduction, and pathological conditions like neurodegenerative diseases or cancer. Validation often includes testing in SNX6-knockout models to confirm specificity. Research utilizing this antibody has contributed to understanding how SNX6 regulates endosomal dynamics and its potential as a therapeutic target in membrane trafficking disorders.
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