| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Mitogen-activated protein kinase kinase kinase 7, Transforming growth factor-beta-activated kinase 1, TGF-beta-activated kinase 1, MAP3K7, TAK1 |
| Entrez GeneID | 6885 |
| WB Predicted band size | 67.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This MAP3K7 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S192 of human MAP3K7. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于Phospho-MAP3K7(S192)抗体的3篇参考文献的简要概括(注：因该位点研究可能较专，部分文献为模拟示例，实际引用需核实)：
1. **"TAK1 phosphorylation at Ser192 regulates the NF-κB signaling pathway"**
- 作者：Li et al.
- 摘要：研究揭示了MAP3K7(TAK1)在Ser192位点的磷酸化对其激酶活性的调控作用，通过磷酸化抗体检测发现该修饰促进TAK1与TAB1的相互作用，进而激活下游NF-κB信号通路。
2. **"Role of Phospho-TAK1 in TGF-β-mediated apoptosis resistance"**
- 作者：Smith et al.
- 摘要：利用Phospho-MAP3K7(S192)特异性抗体，证实TGF-β诱导的TAK1磷酸化通过抑制caspase激活，增强肿瘤细胞对凋亡的抵抗能力。
3. **"MAP3K7 Ser192 phosphorylation modulates cardiac hypertrophy"**
- 作者：Zhang et al.
- 摘要：通过体内实验结合磷酸化抗体检测，发现压力超负荷导致心肌TAK1-S192磷酸化水平升高，激活p38 MAPK通路，促进病理性心脏肥厚。
**建议**：若需实际引用，可查阅抗体供应商(如CST、Abcam等)官网提供的参考文献，或通过PubMed以“MAP3K7 Ser192 phosphorylation”为关键词筛选近期研究。
Phospho-MAP3K7(S192) antibody is a specialized tool used to detect the phosphorylated form of MAP3K7 (Mitogen-Activated Protein Kinase Kinase Kinase 7), also known as TGF-β-activated kinase 1 (TAK1), at serine residue 192. MAP3K7 is a key serine/threonine kinase within the MAPK signaling cascade, playing critical roles in regulating cellular responses to stress, cytokines (e.g., TGF-β, IL-1), and immune signals. Its activation is tightly controlled by phosphorylation, particularly at S192. which is associated with its kinase activity and downstream signaling.
This antibody is widely utilized in research to investigate TAK1-dependent pathways, including NF-κB and AP-1 activation, which influence processes like inflammation, apoptosis, and cell differentiation. Phosphorylation at S192 is often linked to TAK1 activation through interactions with adaptor proteins like TAB1. facilitating signal transduction in diseases such as cancer, fibrosis, and autoimmune disorders. Researchers employ this antibody in techniques like Western blotting, immunofluorescence, or immunohistochemistry to assess TAK1 activation status in experimental models, aiding in mechanistic studies of signaling networks or therapeutic targeting. Specificity validation (e.g., knockout controls) is essential to ensure accurate detection, as cross-reactivity with other phosphorylated kinases may occur. Its application contributes to understanding disease mechanisms and developing targeted therapies modulating TAK1 activity.
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