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Rabbit Polyclonal PSMA5(N-term) Antibody

  • 中文名： PSMA5 (N-term)抗体
  • 别    名： Proteasome subunit alpha type-5, Macropain zeta chain, Multicatalytic endopeptidase complex zeta chain, Proteasome zeta chain, PSMA5
货号: IPDX30186
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesProteasome subunit alpha type-5, Macropain zeta chain, Multicatalytic endopeptidase complex zeta chain, Proteasome zeta chain, PSMA5
Entrez GeneID5686
WB Predicted band size26.4kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis PSMA5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human PSMA5.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是3篇关于PSMA5 (N-term)抗体的参考文献(均为虚拟示例，实际文献需通过学术数据库检索)：

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1. **标题**：*Proteasome subunit α5 (PSMA5) N-terminal antibody validation in human tissue samples*

**作者**：Smith J, et al.

**摘要**：本研究验证了针对PSMA5 N端表位的单克隆抗体在人类肿瘤组织中的特异性，通过Western blot和免疫组化证实其选择性识别降解途径中异常的蛋白酶体亚基表达。

2. **标题**：*Role of PSMA5 in neurodegenerative protein aggregation models*

**作者**：Chen L, et al.

**摘要**：利用PSMA5 (N-term)抗体探究阿尔茨海默病模型中蛋白酶体活性变化，发现其N端结构域在错误蛋白清除中起关键作用，抗体特异性通过siRNA敲除实验验证。

3. **标题**：*Development of a novel PSMA5 N-terminal antibody for proteasome activity profiling*

**作者**：Tanaka K, et al.

**摘要**：报道一种新型高亲和力PSMA5 N端抗体的开发，应用于流式细胞术和免疫共沉淀，揭示其在癌症细胞系中蛋白酶体动态组装的调控机制。

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如需具体文献，建议在PubMed或Google Scholar中搜索关键词“PSMA5 antibody N-terminal”并筛选实验方法部分明确提及该抗体的研究。

背景信息

The PSMA5 (N-term) antibody is a targeted immunological tool used to detect the N-terminal region of the Proteasome 20S Subunit Alpha 5 (PSMA5), a core component of the 20S proteasome complex. PSMA5. part of the ubiquitin-proteasome system, plays a critical role in intracellular protein degradation, regulating processes like cell cycle progression, apoptosis, and stress response. The 20S proteasome consists of α and β subunits arranged in a cylindrical structure, with PSMA5 (α5) contributing to the structural integrity and gating mechanism of the complex. Antibodies targeting the N-terminal region of PSMA5 are designed to recognize specific epitopes near this region, enabling applications such as Western blotting, immunoprecipitation, and immunohistochemistry to study proteasome expression, localization, and assembly. These antibodies are particularly valuable in research on diseases linked to proteasome dysfunction, including cancers, neurodegenerative disorders (e.g., Alzheimer’s, Parkinson’s), and autoimmune conditions. By detecting PSMA5. researchers can investigate proteasome activity under varying physiological or pathological states, evaluate therapeutic inhibitors, or explore mechanisms of drug resistance. Validation of PSMA5 (N-term) antibodies typically involves knockout controls or peptide-blocking assays to confirm specificity. Commercial variants are available from multiple suppliers, often developed in rabbit or mouse hosts with IgG isotypes. Proper handling and storage are essential to maintain antibody performance in experimental workflows.

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