| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Heparan sulfate 2-O-sulfotransferase 1, 2-O-sulfotransferase, 2OST, 282-, HS2ST1, HS2ST, KIAA0448 |
| Entrez GeneID | 9653 |
| WB Predicted band size | 41.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This HS2ST1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 170-200 amino acids from the Central region of human HS2ST1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是关于HS2ST1抗体的参考文献示例(注：以下内容为示例性概括，具体文献需通过学术数据库检索确认)：
---
1. **文献名称**：*HS2ST1-mediated heparan sulfate modification regulates fibroblast growth factor signaling in angiogenesis*
**作者**：Chen et al.
**摘要**：通过HS2ST1抗体进行免疫印迹和免疫荧光实验，验证HS2ST1在血管内皮细胞中的表达，证明其通过修饰硫酸乙酰肝素调控FGF2信号通路，影响血管生成。
---
2. **文献名称**：*HS2ST1-dependent heparan sulfate patterns modulate Wnt signaling in colorectal cancer*
**作者**：Wang et al.
**摘要**：利用HS2ST1抗体分析结直肠癌组织样本，发现HS2ST1表达水平与Wnt/β-catenin通路活性呈负相关，提示其通过硫酸乙酰肝素修饰抑制肿瘤进展。
---
3. **文献名称**：*A monoclonal antibody against HS2ST1 reveals its role in neuronal development*
**作者**：Tanaka et al.
**摘要**：开发并验证一种特异性HS2ST1单克隆抗体，用于小鼠脑组织免疫组化，发现HS2ST1在神经干细胞分化和突触形成中的关键作用。
---
4. **文献名称**：*HS2ST1 knockdown impairs viral entry via altered heparan sulfate interactions*
**作者**：Gupta et al.
**摘要**：通过HS2ST1抗体结合siRNA敲低实验，证明HS2ST1介导的硫酸乙酰肝素修饰影响宿主细胞表面受体结构，从而抑制病毒侵入过程。
---
如需具体文献，建议通过PubMed或Google Scholar检索关键词“HS2ST1 antibody”或“HS2ST1 heparan sulfate”，筛选实验方法中包含抗体应用的研究。
The HS2ST1 antibody targets the enzyme heparan sulfate 2-O-sulfotransferase 1 (HS2ST1), a member of the sulfotransferase family critical for modifying heparan sulfate (HS) proteoglycans. HS2ST1 catalyzes the transfer of sulfate groups to the 2-O position of glucuronic acid residues during HS biosynthesis, influencing the structural and functional diversity of HS chains. These sulfated polysaccharides are essential for regulating key biological processes, including cell signaling, extracellular matrix interactions, and developmental pathways. Dysregulation of HS2ST1 has been implicated in diseases such as cancer, neurodevelopmental disorders, and metabolic conditions.
The HS2ST1 antibody is widely used in research to study the enzyme's expression, localization, and role in HS-dependent mechanisms. It enables detection via techniques like Western blotting, immunohistochemistry, and immunofluorescence, aiding investigations into tissue-specific HS modifications and their pathological implications. Studies utilizing this antibody have highlighted HS2ST1's involvement in FGF2-mediated signaling, Wnt pathway modulation, and tumor metastasis. Additionally, it serves as a tool for exploring therapeutic targets, as HS2ST1 activity impacts angiogenesis, viral entry, and amyloid aggregation in neurodegenerative diseases. Validated antibodies against HS2ST1 are crucial for advancing understanding of HS biology and its translational applications.
×
