| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Threonine aspartase 1, Taspase-1, 3425-, Threonine aspartase subunit alpha, Threonine aspartase subunit beta, TASP1, C20orf13 |
| Entrez GeneID | 55617 |
| WB Predicted band size | 44.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This TASP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 364-395 amino acids from the C-terminal region of human TASP1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于TASP1抗体的3篇参考文献示例(内容基于虚构文献，供参考格式)：
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1. **文献名称**: *"Development and Validation of a Monoclonal Antibody Targeting TASP1 for Proteolytic Activity Studies"*
**作者**: Smith J, et al.
**摘要**: 本研究报道了一种针对TASP1蛋白酶的新型单克隆抗体的开发，验证其特异性并应用于Western blot和免疫荧光检测。抗体成功识别了细胞裂解液中的TASP1前体及其切割后的活性形式，为研究TASP1在肿瘤中的激活机制提供了工具。
2. **文献名称**: *"TASP1 Expression in Acute Leukemia: Role of a Polyclonal Antibody in Clinical Biomarker Analysis"*
**作者**: Lee H, et al.
**摘要**: 通过制备兔源多克隆抗体，作者分析了TASP1在急性白血病患者样本中的表达水平。结果显示TASP1在髓系白血病细胞中显著上调，抗体特异性通过siRNA敲低实验验证，提示TASP1可能作为白血病治疗的潜在靶点。
3. **文献名称**: *"Structural Insights into TASP1 Function via Epitope-Specific Antibody Crystallography"*
**作者**: Garcia R, et al.
**摘要**: 该研究利用针对TASP1催化结构域的小鼠单抗，结合X射线晶体学解析了TASP1的活性位点构象。抗体抑制实验揭示了TASP1在Notch信号通路中的切割机制，为设计小分子抑制剂提供了结构基础。
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(注：以上文献为示例性质，实际文献需通过PubMed或Google Scholar检索关键词如“TASP1 antibody”或“Taspase 1 antibody”获取。)
The TASP1 antibody targets threonine aspartase 1 (TASP1), a protease critical for cleaving epigenetic regulators such as mixed-lineage leukemia (MLL) and histone H3K4 methyltransferase complexes. TASP1-mediated cleavage activates these proteins, enabling proper chromatin remodeling and transcriptional regulation during cellular differentiation and development. Dysregulation of TASP1 has been implicated in cancers, neurodevelopmental disorders, and hematopoiesis abnormalities, as disrupted cleavage of substrates like MLL can lead to oncogenic fusion proteins or impaired gene expression programs.
TASP1 antibodies are essential tools for studying its expression, localization, and enzymatic activity. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess TASP1 levels in tissues or cultured cells. Commercially available antibodies are typically raised in rabbits or mice, with validation in knockout models or siRNA-mediated knockdown to ensure specificity. Recent studies highlight TASP1's role in cancer progression, particularly in leukemia and solid tumors, driving interest in therapeutic targeting. These antibodies also aid in exploring TASP1's interactions with substrates and cofactors, advancing mechanistic insights into epigenetic dysregulation. Continued research using TASP1 antibodies may uncover biomarkers or pathways for precision therapies.
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