| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Importin subunit alpha-3, Importin alpha Q1, Qip1, Karyopherin subunit alpha-4, KPNA4, QIP1 |
| Entrez GeneID | 3840 |
| WB Predicted band size | 57.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This Importin alpha-3 (KPNA4) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the C-terminal region of human Importin alpha-3 (KPNA4). |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) . |
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以下是关于Importin alpha-3 (KPNA4) Antibody (C-term)的参考文献示例：
1. **文献名称**: *"KPNA4-mediated nuclear import of HIV-1 integrase enhances viral replication"*
**作者**: Smith JL, et al.
**摘要**: 本研究揭示了KPNA4通过C端结构域与HIV-1整合酶相互作用，促进其核转运。利用C端特异性抗体阻断KPNA4功能后，显著抑制了病毒在宿主细胞中的复制，表明KPNA4是抗病毒治疗的潜在靶点。
2. **文献名称**: *"Overexpression of Importin alpha-3 (KPNA4) correlates with poor prognosis in colorectal cancer"*
**作者**: Tanaka K, et al.
**摘要**: 通过免疫组化(使用KPNA4 C-term抗体)分析结直肠癌组织样本，发现KPNA4高表达与肿瘤转移和患者生存率降低相关，提示其可作为癌症预后标志物。
3. **文献名称**: *"Importin alpha-3 regulates stress granule dynamics via nuclear transport of RNA-binding proteins"*
**作者**: Chen R, et al.
**摘要**: 本研究通过Western blot和免疫荧光(使用KPNA4 C端抗体)证实，KPNA4在应激条件下调控RNA结合蛋白的核质分布，影响应激颗粒形成及细胞应激响应机制。
4. **文献名称**: *"Structural insights into the C-terminal domain of KPNA4 and its interaction with cargo proteins"*
**作者**: Müller M, et al.
**摘要**: 利用X射线晶体学和抗体结合实验，解析了KPNA4 C端结构域与核定位信号(NLS)的相互作用机制，为设计靶向核转运的小分子抑制剂提供理论依据。
(注：以上文献为示例性质，实际引用需以真实发表文章为准。)
The Importin alpha-3 (KPNA4) Antibody (C-term) is a specialized tool designed to detect the C-terminal region of the KPNA4 protein, a member of the importin alpha family involved in nucleocytoplasmic transport. KPNA4. part of the karyopherin alpha (importin α) protein family, functions as an adaptor molecule that binds cargo proteins containing classical nuclear localization signals (NLS) and facilitates their transport into the nucleus via interaction with importin β1 (KPNB1). This isoform, alpha-3. is distinguished by its tissue-specific expression, with higher levels observed in immune cells, the liver, and testes, suggesting roles in immune regulation, metabolic processes, and reproductive biology.
The antibody’s specificity for the C-terminal region is critical, as this domain mediates interactions with importin β and NLS-containing cargoes. Researchers use this antibody in applications like Western blotting, immunofluorescence, and immunohistochemistry to study KPNA4 expression, subcellular localization, and its involvement in diseases such as cancer, viral infections, and autoimmune disorders. For instance, KPNA4 overexpression has been linked to tumor progression by enhancing nuclear import of oncogenic transcription factors. The antibody’s validation typically includes knockout cell line controls or siRNA knockdown to confirm target specificity. By enabling precise detection of KPNA4. this reagent supports investigations into nuclear transport mechanisms and their pathological implications.
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