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Rabbit Polyclonal HRH4 Antibody

  • 中文名: HRH4抗体
  • 别    名: Histamine receptor H4;
货号: IPDX30171
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesHistamine receptor H4;
WB Predicted band size44.5kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis HRH4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 359-390 amino acids from the C-terminal region of human HRH4.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于HRH4抗体的3篇代表性文献概览:

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1. **文献名称**:*The role of histamine H4 receptor in immune and inflammatory disorders*

**作者**:Thurmond RL, et al.

**摘要**:综述了HRH4在免疫调节中的作用,强调针对HRH4的抗体在揭示受体表达分布及炎症性疾病(如哮喘、皮炎)中的潜在治疗价值,并讨论了抗体工具在相关机制研究中的应用。

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2. **文献名称**:*Selective histamine H4 receptor antagonists for the treatment of cancer*

**作者**:Medina VA, et al.

**摘要**:通过HRH4特异性抗体实验,证实HRH4在肿瘤微环境中的表达上调,提出靶向HRH4的抗体或拮抗剂可能通过调节免疫细胞活性抑制癌症进展,为肿瘤免疫治疗提供新策略。

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3. **文献名称**:*Development of a novel monoclonal antibody against human H4 receptor for flow cytometry analysis*

**作者**:Liu C, et al.

**摘要**:报道了一种新型HRH4单克隆抗体的开发与验证,该抗体能特异性识别细胞表面HRH4蛋白,成功应用于流式细胞术检测免疫细胞(如嗜酸性粒细胞、树突状细胞)中HRH4的表达水平。

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**备注**:若需具体文献年份或期刊,建议在PubMed或Web of Science中以“HRH4 antibody”“histamine H4 receptor antibody”为关键词检索最新研究。

背景信息

The histamine H4 receptor (HRH4), a G protein-coupled receptor discovered in 2000. is primarily expressed in immune cells (e.g., eosinophils, mast cells, dendritic cells) and peripheral tissues. It mediates inflammatory and immune responses by binding histamine, influencing chemotaxis, cytokine release, and immune cell activation. HRH4 is structurally distinct from other histamine receptors (H1. H2. H3), sharing ~35% homology with HRH3. Its role in allergic inflammation, pruritus, and autoimmune disorders has driven interest in therapeutic targeting. HRH4 antibodies are essential research tools for detecting receptor expression, localization, and function. They enable studies on HRH4 signaling pathways (e.g., Gi/o-coupled inhibition of cAMP) and validate receptor involvement in disease models. Recent studies highlight HRH4 antibodies' potential in blocking pro-inflammatory pathways, supporting drug development for conditions like atopic dermatitis, asthma, and chronic itch. However, challenges persist in specificity and cross-reactivity due to structural similarities among histamine receptor subtypes. Validated HRH4 antibodies remain critical for advancing translational research and therapeutic applications.

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