| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | 39S ribosomal protein L24, mitochondrial, L24mt, MRP-L24, MRPL24 |
| Entrez GeneID | 79590 |
| WB Predicted band size | 24.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This MRPL24 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 185-214 amino acids from the C-terminal region of human MRPL24. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于MRPL24抗体的3篇模拟参考文献示例(实际文献需通过数据库检索确认)：
1. **"Structural insights into MRPL24's role in mitochondrial ribosome assembly"**
- **作者**: Zhang Y, et al.
- **摘要**: 通过晶体结构解析，揭示了MRPL24在线粒体核糖体大亚基组装中的关键作用，并验证其抗体在蛋白定位检测中的特异性。
2. **"MRPL24 deficiency disrupts mitochondrial translation and induces metabolic stress"**
- **作者**: Lee S, et al.
- **摘要**: 研究表明MRPL24敲低导致线粒体蛋白质合成障碍，引发细胞代谢异常，利用特异性抗体证实其与核糖体其他组分的相互作用。
3. **"MRPL24 overexpression correlates with poor prognosis in colorectal cancer"**
- **作者**: Wang X, et al.
- **摘要**: 通过免疫组化(使用MRPL24抗体)发现，MRPL24在结直肠癌中高表达，可能通过调控线粒体功能促进肿瘤进展。
4. **"Antibody-based profiling of MRPL24 in neurodegenerative disease models"**
- **作者**: Smith J, et al.
- **摘要**: 利用MRPL24抗体检测帕金森病模型中该蛋白的表达变化，提示其可能参与线粒体功能障碍相关的神经元退化机制。
(注：以上为模拟文献，实际引用请通过PubMed或SciFinder等平台检索。)
The MRPL24 antibody is a research tool designed to detect mitochondrial ribosomal protein L24 (MRPL24), a component of the mitochondrial ribosome's large subunit. Mitochondrial ribosomes are essential for translating mitochondrial DNA-encoded mRNAs into proteins, which are critical subunits of the electron transport chain (ETC) complexes. MRPL24. as part of this machinery, contributes to oxidative phosphorylation (OXPHOS) and cellular energy production. Dysregulation of mitochondrial ribosome proteins, including MRPL24. has been linked to mitochondrial disorders, metabolic diseases, and cancer, where altered energy metabolism is a hallmark.
The MRPL24 antibody is commonly used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to study protein expression, subcellular localization, and mitochondrial function in various biological contexts. Researchers employ it to explore MRPL24's role in mitochondrial biogenesis, stress responses, and disease mechanisms. For instance, studies suggest MRPL24 may influence cancer progression by modulating mitochondrial metabolism or apoptosis.
Available as polyclonal or monoclonal antibodies, MRPL24-specific reagents require validation for specificity and cross-reactivity, often confirmed via knockout cell lines or siRNA silencing. Its utility spans basic mitochondrial biology, translational studies linking mitochondrial dysfunction to diseases, and drug discovery targeting OXPHOS pathways.
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