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Rabbit Polyclonal URKL1(N-term) Antibody

  • 中文名: URKL1 (N-term)抗体
  • 别    名: Uridine-cytidine kinase-like 1, UCKL1, URKL1
货号: IPDX30145
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesUridine-cytidine kinase-like 1, UCKL1, URKL1
Entrez GeneID54963
WB Predicted band size61.1kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis URKL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 60-90 amino acids from the N-terminal region of human URKL1.
FormulationPurified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) .

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参考文献

以下是关于URKL1 (N-term)抗体的参考文献示例(部分信息为假设性描述,建议通过学术数据库进一步核实):

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1. **文献名称**:*URKL1 regulates mitotic progression through its N-terminal domain*

**作者**:Smith A, et al.

**摘要**:本研究利用URKL1 (N-term)抗体进行Western blot和免疫荧光实验,发现URKL1通过其N端结构域与纺锤体蛋白相互作用,调控细胞有丝分裂的稳定性。

2. **文献名称**:*Expression profiling of URKL1 in human cancers using a specific N-terminal antibody*

**作者**:Zhang L, et al.

**摘要**:通过URKL1 (N-term)抗体的免疫组化分析,作者发现URKL1在多种肿瘤组织中高表达,并与患者预后不良相关,提示其作为潜在癌症标志物的可能性。

3. **文献名称**:*Characterization of URKL1 protein-protein interactions via co-immunoprecipitation*

**作者**:Lee J, et al.

**摘要**:该研究使用URKL1 (N-term)抗体进行免疫共沉淀(Co-IP),鉴定了URKL1在DNA损伤修复途径中的新结合蛋白,揭示其N端的关键功能域。

4. **文献名称**:*Development and validation of a polyclonal antibody targeting URKL1 N-terminal region*

**作者**:Johnson R, et al.

**摘要**:文章详细描述了URKL1 (N-term)多克隆抗体的制备流程,验证了其在ELISA、流式细胞术中的应用,并确认了抗体的特异性及灵敏度。

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**注意**:以上文献为示例性内容,实际研究中需通过PubMed、Google Scholar等平台以关键词“URKL1 antibody N-terminal”或“URKL1 N-term”检索真实文献。若研究领域较新或URKL1相关文献较少,可扩大检索范围至相关蛋白家族(如URK/URKL蛋白激酶家族)。

背景信息

The URKL1 (N-term) antibody is designed to specifically target the N-terminal region of the URKL1 protein, a less-characterized member of the uridine-cytidine kinase (UCK) family. URKL1 is thought to play a role in nucleotide metabolism, particularly in phosphorylating uridine and cytidine to support RNA synthesis and cellular proliferation. While its paralog, UCK2. is well-studied in cancer biology and drug activation (e.g., prodrugs like 5-fluorouridine), URKL1's precise functions remain under investigation. The N-terminal antibody enables researchers to detect endogenous URKL1 expression, assess its localization, or study post-translational modifications in this region. It is commonly used in techniques such as Western blotting, immunohistochemistry (IHC), or immunofluorescence (IF) to explore URKL1's role in cellular processes, including cell cycle regulation, DNA damage response, or metabolic pathways. Recent studies suggest URKL1 may have tissue-specific expression patterns or regulatory crosstalk with other kinases, making this antibody a valuable tool for unraveling its biological significance in health and disease contexts, such as cancer or metabolic disorders. Validation typically includes knockout controls to confirm specificity.

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