| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Down syndrome critical region protein 3, Down syndrome critical region protein A, DSCR3, DCRA, DSCRA |
| Entrez GeneID | 10311 |
| WB Predicted band size | 33.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This DSCR3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human DSCR3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于DSCR3(N-term)抗体的模拟参考文献示例(注意：以下内容为示例，非真实文献，仅供参考格式)：
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1. **文献名称**: "Generation and Characterization of a Polyclonal Antibody Targeting the N-terminal Domain of Human DSCR3/RCAN3"
**作者**: Tanaka K, et al.
**摘要**: 本研究报道了一种针对人DSCR3蛋白N端结构域的多克隆抗体的制备与验证。作者通过重组表达DSCR3的N端片段(氨基酸1-100)免疫兔，获得高滴度抗体。Western blot和免疫荧光实验证实该抗体能特异性识别内源性DSCR3.并在多种细胞系中检测到其表达。研究还发现DSCR3在神经元中高表达，提示其可能参与神经系统功能。
2. **文献名称**: "DSCR3 Expression in Down Syndrome: An Immunohistochemical Analysis Using a Novel N-terminal Antibody"
**作者**: Smith JL, et al.
**摘要**: 利用新开发的DSCR3 N端抗体，本文分析了唐氏综合症患者脑组织中DSCR3的分布。结果显示，DSCR3在患者海马区和前额叶皮层的表达显著高于对照组，且与淀粉样斑块沉积区域共定位。该研究支持DSCR3在唐氏综合症病理过程中的潜在作用。
3. **文献名称**: "The Role of DSCR3 in Calcium Signaling: Insights from Antibody-mediated Protein Localization"
**作者**: Chen M, et al.
**摘要**: 通过DSCR3 N端抗体的免疫共沉淀和共聚焦显微技术，本研究揭示了DSCR3与钙调神经磷酸酶(calcineurin)的相互作用。实验表明，DSCR3通过其N端结构域调控钙信号通路，并在HEK293细胞中过表达时抑制calcineurin活性，提示其作为钙信号负调控因子的功能。
4. **文献名称**: "Development of a Monoclonal Antibody for DSCR3 and Its Application in Cancer Cell Proliferation Assays"
**作者**: Gupta R, et al.
**摘要**: 本文描述了一种抗DSCR3 N端的单克隆抗体的开发，并用于研究结肠癌细胞中DSCR3的表达与增殖的关系。结果显示，DSCR3在癌组织中的表达水平与患者预后呈负相关，敲低DSCR3可显著促进癌细胞增殖，表明其可能作为肿瘤抑制因子。
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**提示**：以上为模拟文献，实际研究中请通过PubMed、Google Scholar等平台检索最新文献，关键词可尝试“DSCR3 antibody”、“RCAN3 N-terminal”或结合具体研究领域(如“Down syndrome”、“calcineurin signaling”)。
The DSCR3 (N-term) antibody is designed to target the N-terminal region of the Down Syndrome Critical Region 3 (DSCR3) protein, also known as RCAN3 (Regulator of Calcineurin 3). This gene is located within the Down syndrome critical region on human chromosome 21 (21q22.12) and is implicated in neurodevelopmental and physiological processes. DSCR3 belongs to the RCAN family, which regulates calcineurin, a calcium-dependent phosphatase involved in cell signaling, immune responses, and neuronal development. The protein contains conserved domains that mediate interactions with calcineurin, influencing pathways related to stress adaptation, mitochondrial function, and synaptic plasticity.
The N-terminal region of DSCR3 is critical for its stability, subcellular localization, and functional modulation of calcineurin activity. Antibodies specific to this domain are valuable tools for studying DSCR3 expression, post-translational modifications, and interactions in cellular or tissue contexts. Researchers use the DSCR3 (N-term) antibody in applications like Western blotting, immunofluorescence, and immunohistochemistry to explore its role in Down syndrome-associated pathologies, neurodegenerative disorders, and cardiovascular diseases. Its expression patterns in the brain, heart, and skeletal muscle suggest broader relevance in developmental biology and adaptive cellular responses. Validation of this antibody typically includes testing in knockout models or knockdown systems to confirm specificity, ensuring reliable detection in both physiological and disease-related studies.
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