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Rabbit Polyclonal Phospho-TNFR(S274) Antibody

  • 中文名： Phospho-TNFR(S274)抗体
  • 别    名： Tumor necrosis factor receptor superfamily member 1A, Tumor necrosis factor receptor 1, TNF-R1, Tumor necrosis factor receptor type I, TNF-RI, TNFR-I, p55, p60, CD120a, Tumor necrosis factor receptor superfamily member 1A, membrane form, Tumor necrosis fa
货号: IPDX30131
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesTumor necrosis factor receptor superfamily member 1A, Tumor necrosis factor receptor 1, TNF-R1, Tumor necrosis factor receptor type I, TNF-RI, TNFR-I, p55, p60, CD120a, Tumor necrosis factor receptor superfamily member 1A, membrane form, Tumor necrosis factor-binding protein 1, TBPI, TNFRSF1A, TNFAR, TNFR1
Entrez GeneID7132
WB Predicted band size50.5kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenThis TNFR Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S274 of human TNFR.
FormulationPurified antibody in TBS with 0.05% sodium azide.

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参考文献

以下是模拟生成的关于Phospho-TNFR(S274)抗体的参考文献示例(仅供学术参考，非真实文献)：

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1. **文献名称**：*Phosphorylation of TNFR1 at Serine 274 Modulates Pro-inflammatory Signaling*

**作者**：Smith A, et al.

**摘要**：本研究揭示了TNFR1在S274位点的磷酸化通过招募TRADD蛋白增强NF-κB信号通路，利用Phospho-TNFR(S274)抗体证实了该位点在炎症反应中的关键作用。

2. **文献名称**：*Site-specific Phosphorylation of TNFR Regulates Receptor Internalization*

**作者**：Lee J, et al.

**摘要**：通过Phospho-TNFR(S274)抗体的免疫印迹分析，发现S274磷酸化促进TNFR1内化至内体，进而影响下游JNK信号通路的持续时间。

3. **文献名称**：*Phospho-TNFR(S274) as a Biomarker in Autoimmune Disease Models*

**作者**：Chen X, et al.

**摘要**：在类风湿性关节炎小鼠模型中，使用Phospho-TNFR(S274)抗体检测到该位点磷酸化水平升高，提示其可作为炎症性疾病的潜在治疗靶点。

4. **文献名称**：*Structural Basis of TNFR1 Phosphorylation and Signalosome Assembly*

**作者**：Müller R, et al.

**摘要**：结合晶体学与Phospho-TNFR(S274)抗体的功能实验，阐明S274磷酸化改变受体构象，促进TRAF2/5复合物形成并激活促生存信号。

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如需真实文献，建议通过PubMed或Google Scholar以关键词“TNFR1 S274 phosphorylation”、“TNFR phospho-specific antibody”检索，并筛选涉及信号机制、疾病模型或结构研究的论文。

背景信息

Phospho-TNFR(S274) antibody is a specialized tool used to detect the phosphorylation status of tumor necrosis factor receptor (TNFR) at serine residue 274. TNFRs, including TNFR1 and TNFR2. are transmembrane proteins that play central roles in regulating inflammation, immune responses, and cell survival/apoptosis. Phosphorylation of TNFRs, particularly at specific serine, threonine, or tyrosine residues, is a critical post-translational modification that modulates receptor activity, downstream signaling pathways (e.g., NF-κB, MAPK, or apoptosis cascades), and interactions with adaptor proteins. The S274 phosphorylation site is implicated in fine-tuning TNFR signaling dynamics, potentially influencing receptor internalization, trafficking, or termination of signaling to prevent excessive inflammation. Researchers employ Phospho-TNFR(S274) antibodies in techniques like Western blotting, immunofluorescence, or immunoprecipitation to study TNFR activation mechanisms, signaling crosstalk, or dysregulation in diseases such as autoimmune disorders, cancer, and neurodegenerative conditions. Validating antibody specificity via knockout controls or peptide competition is essential, as phosphorylation-dependent epitopes can be highly context-specific. This antibody aids in elucidating how TNFR post-translational modifications contribute to cellular responses under physiological or pathological states.

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