首页 / 产品 / 抗体 / 一抗

Rabbit Polyclonal Phospho-DAXX(S213) Antibody

  • 中文名: Phospho-DAXX(S213)抗体
  • 别    名: Death domain-associated protein 6, Daxx, hDaxx, ETS1-associated protein 1, EAP1, Fas death domain-associated protein, DAXX, BING2, DAP6
货号: IPDX30123
Price: ¥1280
数量:
大包装询价

验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesDeath domain-associated protein 6, Daxx, hDaxx, ETS1-associated protein 1, EAP1, Fas death domain-associated protein, DAXX, BING2, DAP6
Entrez GeneID1616
WB Predicted band size81.4kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenThis DAXX Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S213 of human DAXX.
FormulationPurified antibody in TBS with 0.05% sodium azide.

+ +

参考文献

以下是基于假设性文献的3-4条关于Phospho-DAXX(S213)抗体的参考文献示例(注意:实际文献需通过数据库验证):

---

1. **文献名称**: "Phosphorylation of DAXX at Serine 213 Modulates TGF-β-Induced Apoptosis in Hepatocellular Carcinoma"

**作者**: Lin, Y. et al.

**摘要**: 研究揭示了TGF-β信号通过磷酸化DAXX(S213位点)调控肝癌细胞凋亡的机制,利用Phospho-DAXX(S213)抗体验证了该修饰在肿瘤微环境中的功能。

2. **文献名称**: "DAXX S213 Phosphorylation Drives Metastatic Progression via MAPK Signaling in Breast Cancer"

**作者**: Wang, H. et al.

**摘要**: 通过Phospho-DAXX(S213)抗体检测,发现S213磷酸化激活MAPK通路,促进乳腺癌侵袭转移,提示其作为潜在治疗靶点。

3. **文献名称**: "Phospho-DAXX(S213) Mediates Neurotoxicity in Alzheimer’s Disease Models"

**作者**: Smith, J. et al.

**摘要**: 在阿尔茨海默病模型中,S213磷酸化DAXX与tau蛋白异常聚集相关,抗体检测表明该修饰可能通过氧化应激加剧神经元损伤。

4. **文献名称**: "DNA Damage Response Requires Dynamic Phosphorylation of DAXX at Serine 213"

**作者**: Johnson, R. et al.

**摘要**: 研究利用Phospho-DAXX(S213)抗体证实,DNA损伤后S213磷酸化招募染色质重塑复合物,调控修复相关基因表达。

---

**备注**:以上文献为示例性质,实际引用需通过PubMed、Web of Science等平台检索具体研究。若抗体为商业化产品,建议参考生产商(如CST、Abcam)官网提供的引用文献。

背景信息

The Phospho-DAXX(S213) antibody is a specialized tool used to detect the phosphorylation status of DAXX (Death-associated protein 6) at serine residue 213. DAXX is a multifunctional protein involved in diverse cellular processes, including apoptosis, transcriptional regulation, and chromatin remodeling. Its activity is tightly regulated by post-translational modifications, particularly phosphorylation, which modulates its interactions with partner proteins and subcellular localization. Phosphorylation at Ser213 has been implicated in DAXX's role in stress response pathways, DNA damage signaling, and regulation of p53-dependent apoptosis. Studies suggest that this modification may influence DAXX's ability to shuttle between nuclear and cytoplasmic compartments, affecting its participation in pro-apoptotic or survival mechanisms depending on cellular context. The Phospho-DAXX(S213) antibody is commonly employed in research focusing on DNA damage response, cancer biology, and neurodegenerative diseases, where DAXX dysregulation has been observed. Validated applications include Western blotting, immunofluorescence, and immunoprecipitation. Researchers use this antibody to investigate signaling crosstalk involving pathways like ATM/ATR, MAPK, or TGF-β, which potentially regulate DAXX phosphorylation. Proper controls, including knockout cell lines or phosphatase treatment, are recommended to confirm specificity, as phosphorylation-dependent antibodies may exhibit cross-reactivity. Commercial versions typically provide species reactivity for human, mouse, and rat samples.

客户数据及评论

折叠内容

大包装询价

×