| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Serine/threonine-protein kinase 19, Protein G11, Protein RP1, STK19, G11, RP1 |
| Entrez GeneID | 8859 |
| WB Predicted band size | 40.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This STK19 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 278-308 amino acids from the C-terminal region of human STK19. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是关于STK19抗体的3篇参考文献示例(内容为模拟，非真实文献)：
---
1. **文献名称**：*STK19 regulates DNA damage response via phosphorylation of BRCA1*
**作者**：Chen Y, et al.
**摘要**：本研究利用特异性STK19抗体，通过免疫沉淀和Western blot技术，揭示了STK19激酶通过磷酸化BRCA1参与DNA损伤修复的机制，为癌症治疗提供了潜在靶点。
2. **文献名称**：*Targeting STK19 in melanoma: Antibody-based therapeutic strategies*
**作者**：Smith JL, et al.
**摘要**：文章报道了一种高亲和力STK19单克隆抗体的开发，并在黑色素瘤模型中验证了其通过抑制STK19活性阻断肿瘤生长的效果，提示其临床转化潜力。
3. **文献名称**：*Expression profiling of STK19 in human tissues using immunohistochemistry*
**作者**：Wang H, et al.
**摘要**：通过多种STK19多克隆抗体进行组织芯片分析，发现STK19在肝脏、肾脏及多种肿瘤中高表达，提示其生理及病理功能多样性，为疾病诊断提供依据。
---
注：以上文献信息为虚构示例，实际引用需查询PubMed或学术数据库获取真实文献。
The STK19 (serine/threonine kinase 19) protein is a nuclear enzyme involved in diverse cellular processes, including DNA repair, transcriptional regulation, and cell cycle control. It phosphorylates substrates such as RNA polymerase II and plays a role in nucleotide excision repair (NER), a critical pathway for resolving UV-induced DNA damage. Dysregulation of STK19 has been implicated in diseases like melanoma, with studies suggesting its overexpression may promote cancer progression by enhancing cell proliferation and metastasis.
STK19 antibodies are essential tools for studying the protein's expression, localization, and functional roles in both normal and pathological contexts. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect STK19 levels in tissues or cell lines. Researchers also employ these antibodies in co-immunoprecipitation (Co-IP) assays to identify interacting partners, shedding light on STK19's molecular networks. Commercially available STK19 antibodies are typically raised against specific epitopes, with validation data confirming specificity through knockout controls or siRNA knockdown. Recent interest in STK19 stems from its potential as a therapeutic target, particularly in cancers linked to UV-induced mutations. However, challenges remain in fully elucidating its signaling mechanisms, underscoring the continued relevance of high-quality antibodies for mechanistic studies.
×
