| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Cyclin-dependent kinase 20, CDK-activating kinase p42, CAK-kinase p42, Cell cycle-related kinase, Cell division protein kinase 20, Cyclin-dependent protein kinase H, Cyclin-kinase-activating kinase p42, CDK20, CCRK, CDCH |
| Entrez GeneID | 23552 |
| WB Predicted band size | 38.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This CCRK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 16-45 amino acids from the N-terminal region of human CCRK. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) . |
+ +
以下是关于CCRK(N-term)抗体的3篇示例参考文献(注：以下内容为示例性虚构文献，实际文献需通过数据库检索获取)：
---
1. **文献名称**: *Development and Validation of a Novel CCRK (N-terminal) Antibody for Cell Cycle Studies*
**作者**: Zhang Y et al.
**摘要**: 本研究开发了一种针对CCRK蛋白N端结构域的高特异性多克隆抗体。通过免疫印迹和免疫组化验证了其在多种癌细胞系中的特异性，并证实该抗体可有效检测CCRK在G1/S期转换中的表达变化，为细胞周期调控研究提供了工具。
2. **文献名称**: *CCRK N-term Antibody Reveals Overexpression in Hepatocellular Carcinoma Tissues*
**作者**: Li H et al.
**摘要**: 利用CCRK N端抗体对肝细胞癌(HCC)组织进行检测，发现CCRK在肿瘤组织中显著高表达，且与患者预后不良相关。研究提示CCRK可能通过调控Wnt/β-catenin通路促进肿瘤进展，该抗体为临床病理分析提供了可靠标记。
3. **文献名称**: *A Phosphorylation-Specific CCRK (N-term) Antibody Identifies Kinase Activity in DNA Damage Response*
**作者**: Chen R et al.
**摘要**: 本文报道了一种可识别CCRK N端磷酸化位点(Ser15)的单克隆抗体。研究发现，DNA损伤条件下CCRK的磷酸化水平升高，该抗体成功用于免疫沉淀和激酶活性检测，揭示了CCRK在DNA修复中的潜在功能。
---
如需真实文献，建议在 **PubMed** 或 **Web of Science** 中检索关键词“CCRK antibody N-terminal”或“Cell Cycle Related Kinase antibody”。
The CCRK (N-term) antibody is a specific immunological tool designed to target the N-terminal region of Cell Cycle-Related Kinase (CCRK), a protein kinase implicated in regulating cell cycle progression and transcriptional activities. CCRK, also known as CDK20 or p42. plays a role in the G1/S phase transition by interacting with cyclin-dependent kinases (CDKs) and modulating pathways such as Wnt/β-catenin signaling. Its dysregulation has been linked to cancers, neurodegenerative disorders, and ciliopathies due to its involvement in cell proliferation and differentiation.
This antibody is typically generated using synthetic peptides or recombinant proteins corresponding to the N-terminal domain of CCRK, ensuring specificity for detecting full-length or truncated isoforms. It is widely used in techniques like Western blotting, immunoprecipitation, and immunofluorescence to study CCRK expression, localization, and interactions in various biological samples. Researchers employ it to explore CCRK's role in tumorigenesis, neuronal development, and cilia function, as well as its potential as a therapeutic target. Validation includes testing in knockout models or siRNA-treated cells to confirm absence of cross-reactivity. Commercial suppliers often provide detailed protocols and application-specific data to support experimental reproducibility.
×
