| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Lethal(2) giant larvae protein homolog 2, HGL, LLGL2 |
| Entrez GeneID | 3993 |
| WB Predicted band size | 113.4kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This LLGL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 940-973 amino acids from the C-terminal region of human LLGL2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) . |
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以下是关于LLGL2抗体的3篇参考文献的简要信息(文献名称、作者及摘要内容概括)：
1. **文献名称**：*LLGL2 suppresses cell migration and invasion through regulating EMT in colorectal cancer*
**作者**：Chen Y, et al.
**摘要**：研究利用LLGL2抗体进行免疫印迹分析，发现LLGL2在结直肠癌中低表达，并通过调控上皮-间质转化(EMT)抑制肿瘤迁移和侵袭。
2. **文献名称**：*Lethal giant larvae 2 enhances the progression of ovarian cancer via PI3K/AKT signaling pathway*
**作者**：Wang L, et al.
**摘要**：通过免疫组化(使用LLGL2抗体)及功能实验，发现LLGL2在卵巢癌中高表达，并通过激活PI3K/AKT通路促进肿瘤进展，提示其作为潜在治疗靶点。
3. **文献名称**：*Loss of LLGL2 in breast cancer cells contributes to metastasis and stemness properties*
**作者**：Zhang H, et al.
**摘要**：研究利用LLGL2抗体进行组织芯片分析，发现LLGL2缺失与乳腺癌转移和肿瘤干细胞特性增强相关，机制涉及Wnt/β-catenin信号通路失调。
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注：以上文献信息为示例，实际文献需通过学术数据库(如PubMed、Web of Science)检索确认。建议结合具体研究领域进一步筛选。
LLGL2 (Lethal(2) giant larvae homolog 2) is a cell polarity protein encoded by the *LLGL2* gene, belonging to the Scribble complex that regulates asymmetric cell division and epithelial polarity. Structurally, it contains WD40 repeats and interacts with other polarity regulators like PAR (partitioning defective) complexes to maintain apical-basal polarity in epithelial tissues. LLGL2 is functionally implicated in cell adhesion, mitotic spindle orientation, and vesicle trafficking.
Research has highlighted its dual role as both a tumor suppressor and context-dependent oncogenic collaborator. Loss of LLGL2 disrupts cell polarity, promoting epithelial-mesenchymal transition (EMT) and metastasis in cancers like breast and lung adenocarcinoma. However, LLGL2 overexpression is linked to poor prognosis in glioblastoma and prostate cancer, suggesting tissue-specific functions.
LLGL2 antibodies are essential tools for detecting protein expression, localization, and post-translational modifications in studies of cancer biology and developmental processes. They are widely used in techniques like Western blot, immunofluorescence, and immunohistochemistry to investigate LLGL2’s interaction networks, phosphorylation status (e.g., by aPKC), and dysregulation in disease models. Recent studies also explore its potential as a therapeutic target or biomarker for metastatic cancers.
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