| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1, PAPS synthase 1, PAPSS 1, Sulfurylase kinase 1, SK 1, SK1, Sulfate adenylyltransferase, ATP-sulfurylase, Sulfate adenylate transferase, SAT, Adenylyl-sulfate kinase, 3'-phosphoadenosine-5'-phosphosulfate synthase, APS kinase, Adenosine-5'-phosphosulfate 3'-phosphotransferase, Adenylylsulfate 3'-phosphotransferase, PAPSS1, ATPSK1, PAPSS |
| Entrez GeneID | 9061 |
| WB Predicted band size | 70.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This PAPSS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 592-624 amino acids from the C-terminal region of human PAPSS1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) . |
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以下是关于PAPSS1 (C-term A607)抗体的参考文献示例(注：以下内容为模拟虚构，仅供参考)：
1. **"PAPSS1 regulates chondrocyte sulfation and skeletal development"**
- **作者**: Li et al.
- **摘要**: 本研究通过PAPSS1 C-term A607抗体进行Western blot和免疫组化分析，发现PAPSS1在小鼠软骨细胞中的特异性表达，并证实其通过调节硫酸盐代谢影响骨骼发育。抗体特异性通过siRNA敲低实验验证。
2. **"Functional characterization of PAPSS1 in hepatic sulfotransferase activity"**
- **作者**: Martinez et al.
- **摘要**: 文章利用PAPSS1 (A607)抗体探究肝脏中硫酸化酶的活性，发现PAPSS1 C端结构域对磺基转移酶复合物的稳定性至关重要。抗体用于免疫共沉淀和亚细胞定位实验。
3. **"PAPSS1 mutations linked to metabolic disorders: A607 antibody-based diagnostic approach"**
- **作者**: Gupta et al.
- **摘要**: 研究使用PAPSS1 C-term A607抗体开发了一种ELISA检测方法，用于筛查与硫酸盐代谢紊乱相关的遗传突变患者，验证了抗体在临床样本中的高特异性和灵敏度。
4. **"PAPSS1 interacts with TGF-β signaling pathway in cancer progression"**
- **作者**: Chen et al.
- **摘要**: 通过A607抗体抑制PAPSS1的C端功能，发现其通过调控TGF-β受体的硫酸化修饰影响肿瘤侵袭性，抗体用于体外功能缺失实验和患者组织微阵列分析。
(注：若需真实文献，建议通过PubMed或Google Scholar以关键词“PAPSS1 antibody A607”或“PAPSS1 C-terminal antibody”检索，并筛选实验方法学或疾病机制相关研究。)
The PAPSS1 (C-term A607) antibody is a polyclonal or monoclonal antibody specifically designed to target the C-terminal region of the human PAPSS1 (3'-phosphoadenosine 5'-phosphosulfate synthase 1) protein, a key enzyme in sulfate metabolism. PAPSS1 catalyzes the synthesis of 3'-phosphoadenosine-5'-phosphosulfate (PAPS), the universal sulfate donor for sulfation reactions critical for glycosaminoglycan synthesis, steroid metabolism, and detoxification pathways. This antibody, often generated using a peptide antigen corresponding to amino acids near the C-terminus (e.g., around residue 607), is commonly used in Western blotting, immunohistochemistry, or immunofluorescence to study PAPSS1 expression, localization, and regulation in various tissues or disease models.
Research applications focus on PAPSS1's role in skeletal development, cartilage function (mutations link to skeletal dysplasias), and cancer (altered sulfation impacts tumor progression). The C-terminal region targeted by this antibody may contain functional domains critical for enzyme activity or interactions with regulatory proteins. Validation typically includes testing in PAPSS1-knockout models or siRNA-treated cells to confirm specificity. Its use helps elucidate PAPSS1's contributions to sulfate homeostasis and pathophysiological conditions, such as metabolic disorders or connective tissue diseases.
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