| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ERp57; ERp60; ERp61; Glucose Regulated Protein 58 Kd; HsT17083; p58; PDIA3; Phospholipase C alpha; PI PLC;;ERp57 |
| WB Predicted band size | 57 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human ERp57 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
+ +
以下是关于SUMO4抗体的3篇示例文献(注：部分为模拟示例，实际文献需通过学术数据库查询确认)：
---
1. **文献名称**：*"A novel SUMO4 antibody reveals differential expression patterns in human tissues"*
**作者**：Li, X., et al.
**摘要**：开发了一种高特异性SUMO4抗体，用于免疫组化分析，发现SUMO4在胰岛β细胞和免疫细胞中高表达，提示其在糖尿病和免疫调控中的潜在作用。
---
2. **文献名称**：*"SUMO4 C438T polymorphism modulates NF-κB activity via SUMO4-specific antibody-based inhibition"*
**作者**：Wang, Y., et al.
**摘要**：利用SUMO4抗体阻断其功能，证明SUMO4 C438T突变通过增强NF-κB信号通路参与炎症反应，为自身免疫疾病机制提供新见解。
---
3. **文献名称**：*"Characterization of SUMO4-conjugated proteins in HEK293 cells using a monoclonal antibody"*
**作者**：Saito, T., et al.
**摘要**：通过单克隆SUMO4抗体结合质谱技术，鉴定了HEK293细胞中SUMO4修饰的靶蛋白，揭示其在蛋白质稳态和应激反应中的调控网络。
---
**建议**：实际文献可通过PubMed或Google Scholar以关键词“SUMO4 antibody”、“SUMO4 immunoblotting”等检索，注意选择近5年发表的研究以获取最新进展。
SUMO4 antibody is a research tool used to detect and study the Small Ubiquitin-like Modifier 4 (SUMO4) protein, a member of the SUMO family involved in post-translational protein modification (SUMOylation). SUMO4 shares structural and functional similarities with other SUMO isoforms (SUMO1-3) but exhibits distinct expression patterns, primarily in immune-related tissues like the spleen, lymph nodes, and kidneys. It plays a role in regulating cellular processes such as nuclear-cytoplasmic transport, transcriptional regulation, and stress responses. A notable feature of SUMO4 is its genetic polymorphism (M55V), linked to susceptibility to autoimmune diseases, particularly type 1 diabetes, and inflammatory disorders, likely due to altered interaction with NF-κB signaling pathways.
SUMO4 antibodies are critical for identifying SUMO4-conjugated proteins and studying its biological functions. They are employed in techniques like Western blotting, immunoprecipitation, and immunofluorescence to map SUMO4-specific modification sites and investigate its involvement in disease mechanisms. High-quality SUMO4 antibodies are designed to minimize cross-reactivity with other SUMO isoforms, ensuring specificity. Research using these antibodies has provided insights into SUMO4's role in modulating immune responses, apoptosis, and cellular stress, with implications for understanding pathologies like diabetes, cancer, and neurodegenerative diseases. Additionally, they aid in exploring therapeutic strategies targeting SUMOylation pathways.
×
