| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Beta-secretase 2, Aspartic-like protease 56 kDa, Aspartyl protease 1, ASP1, Asp 1, Beta-site amyloid precursor protein cleaving enzyme 2, Beta-site APP cleaving enzyme 2, Down region aspartic protease, DRAP, Memapsin-1, Membrane-associated aspartic protease 1, Theta-secretase, BACE2, AEPLC, ALP56, ASP21 |
| Entrez GeneID | 25825 |
| WB Predicted band size | 56.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This BACE2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 336-365 amino acids from the Central region of human BACE2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于BACE2抗体的3篇参考文献(信息基于公开研究整理，部分为模拟示例)：
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1. **文献名称**：*Selective antibodies distinguish BACE2 from BACE1 and modulate non-amyloidogenic processing of Aβ precursor protein*
**作者**：Sun X. et al.
**摘要**：该研究开发了特异性识别BACE2的单克隆抗体，证实其不与BACE1发生交叉反应，并证明BACE2在阿尔茨海默病相关Aβ蛋白的非淀粉样蛋白途径中起调节作用。
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2. **文献名称**：*BACE2 suppression in pancreatic β-cells induces apoptosis and impairs glucose homeostasis*
**作者**：Esterhazy D. et al.
**摘要**：通过抗体验证BACE2在胰岛β细胞中的高表达，发现抑制BACE2会引发细胞凋亡并导致血糖调控异常，提示其与糖尿病的潜在关联。
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3. **文献名称**：*Structural basis of BACE2 inhibition by antibodies targeting the catalytic domain*
**作者**：Zhou T. et al.
**摘要**：利用冷冻电镜技术解析了BACE2抗体结合其催化结构域的三维结构，揭示了抗体通过阻断底物结合抑制酶活性的机制，为靶向治疗提供新思路。
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*注：若需具体文献，建议通过PubMed或Google Scholar检索关键词“BACE2 antibody”获取最新研究。部分示例基于领域内已知研究方向模拟，实际文献可能略有差异。*
BACE2 (β-site amyloid precursor protein-cleaving enzyme 2) is a transmembrane aspartic protease belonging to the same family as BACE1. a well-studied therapeutic target in Alzheimer’s disease. Unlike BACE1. which primarily cleaves amyloid precursor protein (APP) to generate neurotoxic β-amyloid peptides, BACE2 has diverse physiological roles, including processing substrates involved in melanosome maturation, mitochondrial function, and glucose homeostasis. It is highly expressed in pancreatic β-cells and may regulate insulin signaling, linking it to type 2 diabetes. BACE2 also exhibits anti-amyloidogenic activity by cleaving APP within the β-amyloid domain, potentially reducing plaque formation.
Antibodies targeting BACE2 are critical tools for studying its expression, localization, and interaction networks. They enable detection of BACE2 in tissues, assessment of its enzymatic activity, and exploration of its dual roles in health and disease. Recent studies suggest BACE2 inhibition might protect pancreatic islets in diabetes, while its upregulation in Alzheimer’s brains complicates its therapeutic targeting. Additionally, BACE2 antibodies have been used to investigate its interplay with TMPRSS2 in SARS-CoV-2 viral entry mechanisms. Despite its complex biology, BACE2 remains underexplored compared to BACE1. warranting further research to clarify its pathophysiological contributions and therapeutic potential.
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