| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CK; CMK; UMK; CMPK; UMPK; UMP-CMPK |
| WB Predicted band size | 22 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于 ABCB10 (N-term) 抗体的参考文献示例(文献信息为虚构模拟，仅作参考)：
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1. **"ABCB10 regulates mitochondrial iron homeostasis through interaction with ferrochelatase"**
*Authors: Smith J, Brown K, Lee R.*
摘要：本研究利用针对 ABCB10 N 端结构域的特异性抗体，揭示了 ABCB10 在线粒体铁代谢中的作用，发现其通过与亚铁螯合酶(ferrochelatase)互作调控血红素合成。
2. **"ABCB10 deficiency impairs erythroid differentiation via disrupting heme biosynthesis"**
*Authors: Chen L, Wang H, Zhang Y.*
摘要：通过 ABCB10 (N-term) 抗体的免疫沉淀实验，证明 ABCB10 缺失导致红细胞分化异常，其机制与血红素生物合成通路中关键蛋白的稳定性下降相关。
3. **"Targeting ABCB10 in mitochondrial antioxidant defense: Insights from knockout models"**
*Authors: Gupta S, Patel T, Adams M.*
摘要：研究使用 N 端特异性抗体进行 Western blot 分析，发现 ABCB10 通过调控线粒体谷胱甘肽转运参与抗氧化防御，其缺失加剧氧化应激诱导的细胞损伤。
4. **"ABCB10 interacts with mitoferrin-1 to coordinate mitochondrial iron transport"**
*Authors: Kim D, Rossi M, Garcia J.*
摘要：利用 ABCB10 N 端抗体进行共聚焦成像，证实 ABCB10 与线粒体铁转运蛋白 mitoferrin-1 共定位，协同维持细胞内铁稳态及线粒体功能。
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注：以上文献信息为示例，实际引用时请以真实发表的论文为准。建议通过 PubMed 或 Web of Science 搜索关键词 "ABCB10 antibody N-terminal" 获取具体文献。
The ABCB10 (N-term) antibody is a targeted reagent used to detect the N-terminal region of the ATP-binding cassette subfamily B member 10 (ABCB10), a mitochondrial transmembrane protein predominantly localized in the inner mitochondrial membrane. ABCB10. part of the ABC transporter family, plays a critical role in mitochondrial function, particularly in heme biosynthesis and redox homeostasis. It interacts with ferrochelatase, the terminal enzyme in heme synthesis, and supports the transport of metabolites across the mitochondrial membrane. The N-terminal domain is essential for its stability and interaction with partner proteins.
This antibody is widely utilized in research to study ABCB10's expression, localization, and molecular mechanisms in physiological and pathological contexts, such as erythropoiesis, mitochondrial disorders, and diseases linked to oxidative stress (e.g., anemia, neurodegeneration). Validated applications include Western blotting, immunofluorescence, and immunohistochemistry, enabling visualization of ABCB10 in cell lines or tissue samples. By targeting the N-terminal epitope, the antibody helps distinguish ABCB10 from other ABC transporters, ensuring specificity in experimental assays. Its utility extends to exploring therapeutic strategies for mitochondrial dysfunction and hematologic abnormalities, underscoring its importance in cellular and molecular biology research.
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