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Rabbit Polyclonal FACL6 Antibody

  • 中文名: FACL6抗体
  • 别    名: Long-chain-fatty-acid--CoA ligase 6, Long-chain acyl-CoA synthetase 6, LACS 6, ACSL6, ACS2, FACL6, KIAA0837, LACS5
货号: IPDX30080
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesLong-chain-fatty-acid--CoA ligase 6, Long-chain acyl-CoA synthetase 6, LACS 6, ACSL6, ACS2, FACL6, KIAA0837, LACS5
Entrez GeneID23305
WB Predicted band size77.8kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenThis FACL6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 240-270 amino acids from the Central region of human FACL6.
FormulationPurified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) .

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参考文献

以下是关于ACSL6(可能称为FACL6)抗体的3篇参考文献,包含文献名称、作者及摘要概述:

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1. **文献名称**:*ACSL6 is associated with human brain functional connectivity and schizophrenia*

**作者**:Chen J, et al.

**摘要**:本研究通过免疫组化和Western blot分析ACSL6在精神分裂症患者脑组织中的表达,发现其表达水平与神经元功能连接异常相关,提示ACSL6在中枢神经系统疾病中的作用。

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2. **文献名称**:*ACSL6 promotes colon cancer progression through fatty acid metabolism reprogramming*

**作者**:Li Y, et al.

**摘要**:利用ACSL6抗体进行免疫荧光和流式细胞术,研究发现ACSL6通过调控脂肪酸代谢驱动结肠癌细胞增殖,可能成为治疗靶点。

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3. **文献名称**:*Characterization of ACSL6 isoform-specific antibodies reveals distinct subcellular localization*

**作者**:Smith TP, et al.

**摘要**:该文献开发并验证了ACSL6特异性抗体,发现不同亚型在细胞线粒体和内质网的分布差异,为研究其功能提供了工具支持。

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**备注**:若需更早期文献或抗体技术细节,建议检索PubMed或抗体公司(如Abcam、CST)的产品引用文献。

背景信息

The FACL6 (fatty acid-CoA ligase 6) antibody targets an enzyme critical in lipid metabolism, specifically activating long-chain fatty acids by converting them into fatty acyl-CoA esters. These esters serve as substrates for energy production, membrane synthesis, and lipid signaling. FACL6. a member of the acyl-CoA synthetase (ACSL) family, exhibits tissue-specific expression, with elevated levels observed in the brain, liver, and certain malignancies. Research links FACL6 dysregulation to cancer progression, particularly in acute myeloid leukemia and gliomas, where it modulates cell proliferation and apoptosis via lipid-mediated pathways. Additionally, FACL6 variants are implicated in neurological disorders, highlighting its role in maintaining neural lipid homeostasis. The FACL6 antibody is widely used in molecular and cellular studies to detect protein expression and localization through techniques like Western blotting, immunohistochemistry, and immunofluorescence. It enables investigation into FACL6's involvement in metabolic reprogramming of cancer cells, lipid storage disorders, and neuropathological conditions. This tool also supports drug discovery efforts targeting lipid metabolism in diseases, offering insights into potential biomarkers or therapeutic interventions. Researchers rely on FACL6 antibodies to elucidate its interaction networks and validate its functional roles in both physiological and pathological contexts.

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