| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1, ADP-ribosyltransferase C2 and C3 toxin-like 1, ARTC1, Mono(ADP-ribosyl)transferase 1, CD296, ART1 |
| Entrez GeneID | 417 |
| WB Predicted band size | 36.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This ART1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 14-43 amino acids from the N-terminal region of human ART1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ART1(N-term)抗体的3篇参考文献示例(注：文献为虚拟示例，实际引用需核实):
1. **"Characterization of ART1 N-terminal domain antibody in cancer cell signaling"**
*Author: Müller et al. (2018)*
摘要: 开发并验证针对ART1蛋白N端表位的单克隆抗体，证实其在结肠癌细胞膜定位及ADP-核糖基化功能研究中的应用，揭示ART1通过修饰细胞表面蛋白影响肿瘤微环境。
2. **"ART1-mediated ADP-ribosylation regulates T cell activation"**
*Author: Zhang et al. (2020)*
摘要: 利用ART1 N端特异性抗体揭示其在T细胞受体信号通路中的作用，证明ART1通过调节LAT蛋白的核糖基化影响免疫突触形成，为自身免疫疾病治疗提供新靶点。
3. **"Novel ART1 antibody reveals tissue-specific expression patterns"**
*Author: Watanabe et al. (2021)*
摘要: 报道高特异性兔源多克隆抗体的开发，通过免疫组化证实ART1在心脏、骨骼肌和肿瘤血管内皮细胞的差异性表达，为心血管疾病研究提供工具。
建议通过PubMed或Web of Science使用关键词 "ART1 antibody N-terminal" 或 "ARTC1 antibody" 检索真实文献。实际研究中需注意抗体货号(如Santa Cruz sc-xxxx)及物种反应性验证数据。
The ART1 (N-term) antibody is designed to target the N-terminal region of ADP-ribosyltransferase 1 (ART1), a member of the ADP-ribosyltransferase family. ART1 is a glycosylphosphatidylinositol (GPI)-anchored enzyme that catalyzes the transfer of ADP-ribose groups from nicotinamide adenine dinucleotide (NAD+) to specific protein substrates, modulating their activity in processes like cell signaling, inflammation, and immune regulation. This post-translational modification influences cellular functions such as ion channel activity, receptor trafficking, and apoptosis.
The N-terminal domain of ART1 is critical for its enzymatic function and substrate interaction. Antibodies targeting this region are widely used in research to study ART1 expression, localization, and regulatory roles in physiological or pathological contexts. For instance, ART1 has been implicated in cancer progression, autoimmune diseases, and cardiovascular disorders, where its dysregulation may contribute to disease mechanisms. The ART1 (N-term) antibody is commonly employed in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect endogenous ART1 levels in tissues or cell lines. Its specificity for the N-terminus ensures recognition of full-length ART1. aiding in distinguishing it from proteolytic fragments or splice variants. Validation of this antibody typically includes verification in knockout models or siRNA-treated samples to confirm target specificity.
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