| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Ubiquitin carboxyl-terminal hydrolase 16 {ECO:0000255|HAMAP-Rule:MF_03062}, 341912 {ECO:0000255|HAMAP-Rule:MF_03062}, Deubiquitinating enzyme 16 {ECO:0000255|HAMAP-Rule:MF_03062}, Ubiquitin thioesterase 16 {ECO:0000255|HAMAP-Rule:MF_03062}, Ubiquitin-processing protease UBP-M, Ubiquitin-specific-processing protease 16 {ECO:0000255|HAMAP-Rule:MF_03062}, USP16 {ECO:0000255|HAMAP-Rule:MF_03062} |
| Entrez GeneID | 10600 |
| WB Predicted band size | 93.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This USP16 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 386-416 amino acids from the Central region of human USP16. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是3篇与USP16抗体相关的模拟参考文献示例(文献内容为模拟概括，建议通过学术数据库核实具体信息)：
---
1. **文献名称**: *USP16 modulates stem cell self-renewal by regulating histone H2A deubiquitination*
**作者**: Zhang Y, et al.
**摘要**: 本研究利用USP16特异性抗体，通过免疫沉淀和Western blot技术，揭示了USP16通过去泛素化组蛋白H2A调控胚胎干细胞的自我更新能力，并证明其缺失导致分化异常。
---
2. **文献名称**: *USP16 overexpression correlates with poor prognosis in breast cancer*
**作者**: Suresh B, et al.
**摘要**: 通过免疫组化(IHC)分析乳腺癌组织中USP16抗体的表达水平，发现USP16高表达与肿瘤侵袭性和患者生存率降低显著相关，提示其作为潜在预后标志物的价值。
---
3. **文献名称**: *USP16 regulates DNA damage response via stabilizing BRCA1-BARD1 complex*
**作者**: Lee JH, et al.
**摘要**: 研究利用USP16抗体进行共聚焦显微成像和染色质免疫共沉淀(ChIP)，证明USP16通过去泛素化BRCA1-BARD1复合物调控DNA损伤修复通路，影响基因组稳定性。
---
4. **文献名称**: *Development of a monoclonal antibody targeting USP16 for therapeutic inhibition*
**作者**: Wang X, et al.
**摘要**: 报道了一种新型USP16单克隆抗体的开发，通过体外实验验证其特异性结合能力，并证明该抗体可有效抑制USP16的酶活，为相关疾病治疗提供潜在工具。
---
**备注**：以上文献信息为模拟概括，实际引用时请通过PubMed、Web of Science等平台检索具体文献并核对内容。
USP16 (Ubiquitin-Specific Protease 16) is a deubiquitinating enzyme belonging to the ubiquitin-specific protease family, which regulates protein stability and function by removing ubiquitin moieties from target substrates. It plays critical roles in diverse cellular processes, including cell cycle regulation, chromatin remodeling, DNA repair, and stem cell differentiation. USP16 is notably involved in modulating histone H2A deubiquitination, influencing epigenetic regulation and genomic stability. Dysregulation of USP16 has been linked to various diseases, such as cancer, neurodegenerative disorders, and Down syndrome, where its overexpression or altered activity may contribute to pathological phenotypes.
USP16 antibodies are essential tools for studying its expression, localization, and molecular interactions in both physiological and disease contexts. These antibodies enable researchers to detect USP16 protein levels via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Additionally, they facilitate functional studies, such as identifying USP16-binding partners through co-immunoprecipitation or exploring its role in substrate-specific deubiquitination. Commercially available USP16 antibodies are typically validated for specificity and reactivity across human, mouse, or rat samples, though optimization may be required for specific applications. Research using USP16 antibodies continues to uncover its therapeutic potential, particularly in targeting USP16-mediated pathways for cancer treatment or mitigating genomic instability.
×
