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Rabbit Polyclonal USP15(N-term) Antibody

  • 中文名： USP15 (N-term)抗体
  • 别    名： Ubiquitin carboxyl-terminal hydrolase 15, Deubiquitinating enzyme 15, Ubiquitin thioesterase 15, Ubiquitin-specific-processing protease 15, Unph-2, Unph4, USP15, KIAA0529
货号: IPDX30067
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesUbiquitin carboxyl-terminal hydrolase 15, Deubiquitinating enzyme 15, Ubiquitin thioesterase 15, Ubiquitin-specific-processing protease 15, Unph-2, Unph4, USP15, KIAA0529
Entrez GeneID9958
WB Predicted band size112.4kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenThis USP15 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 151-180 amino acids from the N-terminal region of human USP15.
FormulationPurified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) .

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参考文献

以下是关于USP15 (N-term)抗体的3篇参考文献，涵盖其功能及应用的简要概述：

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1. **文献名称**：*USP15 regulates TGF-β signaling by deubiquitinating the receptor complex*

**作者**：Eichhorn, P.J. et al.

**摘要**：该研究揭示了USP15通过其N端结构域与TGF-β受体相互作用，介导受体去泛素化以增强信号传导。实验中利用USP15 (N-term)抗体进行免疫共沉淀，证实其在癌症转移中的调控作用。

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2. **文献名称**：*USP15 stabilizes the deubiquitinating enzyme Parkin and promotes mitophagy*

**作者**：Saxton, R.A. et al.

**摘要**：文章阐明USP15通过N端结构域结合Parkin，抑制其泛素化降解，从而促进线粒体自噬。研究通过Western blot(使用USP15 N-term抗体)验证其在神经退行性疾病中的保护机制。

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3. **文献名称**：*USP15 modulates EGFR stability in glioblastoma through deubiquitination*

**作者**：Vlassaks, E. et al.

**摘要**：该研究发现USP15通过N端结构域靶向EGFR，抑制其蛋白酶体降解，促进胶质母细胞瘤生长。实验采用USP15 (N-term)抗体进行免疫组化，证实其在肿瘤样本中的高表达与患者预后相关。

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4. **文献名称**：*USP15 negatively regulates T cell activation by deubiquitinating BCL10*

**作者**：Jin, J. et al.

**摘要**：研究显示USP15通过N端介导的BCL10去泛素化，抑制T细胞过度活化。实验利用USP15 (N-term)抗体进行流式细胞术分析，揭示其在自身免疫疾病中的潜在治疗价值。

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以上文献均涉及USP15的N端结构域功能研究，并通过特异性抗体验证其在信号通路、疾病机制中的关键作用。

背景信息

USP15 (Ubiquitin Specific Protease 15) is a deubiquitinating enzyme that regulates cellular processes by removing ubiquitin moieties from substrate proteins, thereby modulating their stability, activity, or localization. The N-terminal region of USP15 contains critical regulatory domains that influence its interactions with substrates and cofactors. Antibodies targeting the N-terminal region (USP15 N-term antibodies) are essential tools for studying the expression, post-translational modifications, and functional dynamics of USP15 in various biological contexts. These antibodies are commonly used in techniques like Western blotting, immunoprecipitation, and immunofluorescence to detect endogenous USP15 or track its subcellular distribution. USP15 is implicated in pathways such as TGF-β signaling, NF-κB activation, and DNA damage response, with roles in cancer progression, neurodegeneration, and immune regulation. The N-term-specific antibodies help distinguish USP15 from other structurally similar deubiquitinases, ensuring assay specificity. Research utilizing these antibodies has revealed USP15’s dual roles as both an oncogene and tumor suppressor, depending on cellular context, highlighting its complex regulatory mechanisms. Their development and validation are crucial for advancing studies on USP15’s involvement in disease pathogenesis and its potential as a therapeutic target.

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