| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100 | Human,Mouse,Rat |
| ICC | 1/10-1/50 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Ubiquitin-conjugating enzyme E2 K, Huntingtin-interacting protein 2, HIP-2, Ubiquitin carrier protein, Ubiquitin-conjugating enzyme E2-25 kDa, Ubiquitin-conjugating enzyme E2(25K), Ubiquitin-conjugating enzyme E2-25K, Ubiquitin-protein ligase, UBE2K, HIP2, LIG |
| Entrez GeneID | 3093 |
| WB Predicted band size | 22.4kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This HIP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 109-139 amino acids from the Central region of human HIP2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) . |
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以下是关于HIP2抗体的3篇参考文献，按研究领域分类简要概括：
1. **文献名称**：*HSPA2 (HSP70-2) antibody specifically recognizes male germ cells in humans and mammals*
**作者**：Kurpisz M et al.
**摘要**：研究验证了HIP2(HSPA2)抗体在人类和小鼠睾丸组织中的特异性，发现其标记精子发生过程中的生殖细胞，提示其在男性不育症研究中的应用潜力。
2. **文献名称**：*Prognostic value of HIP2 expression in breast cancer and its role in chemotherapy resistance*
**作者**：Wang Y et al.
**摘要**：利用HIP2抗体检测乳腺癌组织中的HIP2蛋白表达水平，发现高表达与患者预后不良及化疗耐药相关，可能作为治疗靶点。
3. **文献名称**：*HIP2 antibody-based detection of protein aggregates in neurodegenerative models*
**作者**：Smith JL et al.
**摘要**：开发了一种新型HIP2单克隆抗体，用于特异性识别阿尔茨海默病模型中异常折叠的tau蛋白聚集体，为神经退行性疾病诊断提供新工具。
注：HIP2(HSPA2)是热休克蛋白家族成员，相关研究多集中于生殖生物学、癌症及神经疾病领域。实际文献需通过PubMed/Google Scholar检索确认最新进展。
HIP2 (HCF-1 interacting protein 2), also known as UBE2K, is a ubiquitin-conjugating enzyme (E2) involved in the ubiquitin-proteasome system (UPS), a critical pathway for protein degradation and homeostasis. It catalyzes the transfer of ubiquitin to substrate proteins in conjunction with E3 ubiquitin ligases, tagging them for proteasomal degradation. HIP2 plays roles in diverse cellular processes, including cell cycle regulation, DNA repair, and stress response.
Research has linked HIP2 to neurodegenerative diseases, such as Huntington’s and Alzheimer’s, where its dysfunction may contribute to abnormal protein aggregation. In cancer, HIP2 exhibits dual roles—promoting apoptosis under certain stress conditions while supporting tumor survival in others, highlighting context-dependent regulatory mechanisms.
HIP2 antibodies are essential tools for studying its expression, localization, and interactions. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate HIP2’s involvement in disease pathways or therapeutic responses. Recent studies also explore HIP2 as a potential biomarker or drug target, particularly in cancers and neurodegeneration. However, its complex regulatory networks warrant further exploration to clarify its therapeutic implications.
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