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Rabbit Polyclonal Bmp7(N-term) Antibody

  • 中文名: Bmp7 (N-term)抗体
  • 别    名: Bone morphogenetic protein 7, BMP-7, Osteogenic protein 1, OP-1, Eptotermin alfa, BMP7, OP1
货号: IPDX30058
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 1/50-1/100 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesBone morphogenetic protein 7, BMP-7, Osteogenic protein 1, OP-1, Eptotermin alfa, BMP7, OP1
Entrez GeneID655
WB Predicted band size49.3kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis Bmp7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 15-44 amino acids from the N-terminal region of human Bmp7.
FormulationPurified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) .

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参考文献

以下是3篇涉及BMP7(N-term)抗体使用的研究文献摘要概括(基于公开数据模拟,非真实文献):

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1. **"BMP7 regulates early embryonic kidney development through SMAD signaling"**

*作者:Smith J et al.*

摘要:研究利用BMP7 (N-term)特异性抗体(来源:Abcam, cat# ab12345)进行小鼠胚胎肾脏组织的免疫组化分析,证实BMP7在肾小管形成中的时空表达模式,并揭示其通过SMAD1/5通路调控细胞分化。

2. **"N-terminal BMP7 antibody blocks adipogenic differentiation in mesenchymal stem cells"**

*作者:Li X et al.*

摘要:通过Western blot和中和实验验证BMP7 (N-term)抗体(Santa Cruz, sc-9876)可特异性识别并抑制BMP7蛋白功能,证明BMP7在脂肪形成中的关键作用,为代谢疾病研究提供工具。

3. **"BMP7 promotes osteogenesis via MAPK pathway in bone repair models"**

*作者:Garcia R et al.*

摘要:采用BMP7 (N-term)抗体(Proteintech, 6789-1)对大鼠骨折愈合组织进行免疫荧光染色,发现BMP7在成骨细胞前体细胞中高表达,并通过p38 MAPK信号通路促进骨基质沉积。

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**注**:以上文献为模拟示例,实际引用时需通过PubMed或Google Scholar检索真实文献(可尝试关键词:**BMP7 antibody N-terminal, BMP7 epitope mapping**)。推荐检查抗体供应商(如Abcam、CST)官网提供的引用文献列表。

背景信息

The Bmp7 (N-term) antibody is a targeted reagent designed to detect the N-terminal region of Bone Morphogenetic Protein 7 (BMP7), a member of the transforming growth factor-beta (TGF-β) superfamily. BMP7 plays critical roles in embryonic development, tissue repair, and homeostasis, particularly in bone and cartilage formation, kidney development, and neural patterning. It functions by binding to serine/threonine kinase receptors, activating SMAD signaling pathways to regulate gene expression. The antibody is typically raised in immunized hosts (e.g., rabbit, mouse) using synthetic peptides or recombinant proteins corresponding to the N-terminal epitope of BMP7. This design ensures specificity for full-length BMP7 or its isoforms containing the N-terminal domain, distinguishing it from other BMP family members. Validated applications include Western blotting, immunohistochemistry, and immunofluorescence, aiding in studies of BMP7 expression in developmental biology, organogenesis, and diseases like chronic kidney disease or cancer. Researchers use this antibody to explore BMP7's therapeutic potential or its dysregulation in pathological conditions. Proper controls, such as knockout tissues or blocking peptides, are recommended to confirm signal specificity.

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