首页 / 产品 / 抗体 / 一抗

Rabbit Polyclonal Recoverin Antibody

  • 中文名： Recoverin抗体
  • 别    名： Recoverin, Cancer-associated retinopathy protein, Protein CAR, RCVRN, RCV1
货号: IPDX30056
Price： ￥1180
数量：
大包装询价

验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesRecoverin, Cancer-associated retinopathy protein, Protein CAR, RCVRN, RCV1
Entrez GeneID5957
WB Predicted band size23.1kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis Recoverin antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 169-200 amino acids from the C-terminal region of human Recoverin.
FormulationPurified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) .

+ +

参考文献

以下是关于Recoverin抗体的3篇参考文献及其简要摘要：

1. **《Recoverin as a paraneoplastic antigen in cancer-associated retinopathy》**

- 作者：Thirkill, C.E. 等(1992)

- 摘要：该研究首次报道Recoverin抗体与癌症相关视网膜病变(CAR)的关联，发现CAR患者血清中存在针对Recoverin的自身抗体，提示其可能通过攻击视网膜细胞引发视力丧失。

2. **《Autoantibodies against the calcium-binding protein Recoverin in sera of patients with paraneoplastic retinopathy》**

- 作者：Polans, A.S. 等(1993)

- 摘要：研究证实Recoverin是CAR的关键自身抗原，通过克隆Recoverin基因并分析患者抗体反应，揭示了其在小细胞肺癌等肿瘤中的异常表达触发的自身免疫反应。

3. **《ELISA detection of anti-Recoverin antibodies in cancer-associated retinopathy》**

- 作者：Shiraga, S. 等(2002)

- 摘要：开发了一种基于ELISA的Recoverin抗体检测方法，用于CAR的临床诊断，并验证了其在区分CAR与其他视网膜疾病中的敏感性和特异性。

4. **《Recoverin antibody-associated retinopathy without cancer: implications for autoimmune etiology》**

- 作者：Kikuchi, T. 等(2003)

- 摘要：报道了非肿瘤患者中出现Recoverin抗体阳性的视网膜病变病例，提示Recoverin自身免疫反应可能独立于恶性肿瘤发生，扩展了其临床意义。

背景信息

Recoverin antibodies are autoantibodies targeting recoverin, a calcium-binding protein expressed primarily in retinal photoreceptor cells. Discovered in the 1990s, recoverin plays a role in modulating phototransduction by regulating rhodopsin kinase activity in response to calcium levels. Its association with autoimmune retinopathy emerged when recoverin was identified as a key antigen in cancer-associated retinopathy (CAR), a paraneoplastic syndrome often linked to small-cell lung carcinoma or other malignancies. In CAR, immune cross-reactivity between tumor antigens and retinal proteins triggers antibody-mediated attacks on photoreceptors, leading to progressive vision loss, photophobia, and night blindness. Recoverin antibodies are also detected in melanoma-associated retinopathy (MAR) and some non-paraneoplastic autoimmune retinopathies. Structurally, recoverin contains EF-hand calcium-binding motifs, and its immunogenicity may relate to calcium-dependent conformational changes exposing cryptic epitopes. Diagnosis involves detecting recoverin antibodies in serum or ocular fluids via Western blot, ELISA, or cell-based assays. While their pathogenic mechanism remains debated, these antibodies are thought to induce photoreceptor apoptosis through calcium dysregulation or direct cellular entry. Clinical management focuses on immunosuppression, tumor treatment (if applicable), and plasma exchange. Research continues to explore recoverin's role in retinal physiology and its interplay with autoimmune responses.

客户数据及评论

折叠内容

大包装询价

×