| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Gap junction alpha-9 protein, Connexin-58, Cx58, Connexin-59, Cx59, Gap junction alpha-10 protein, GJA9, GJA10 |
| Entrez GeneID | 81025 |
| WB Predicted band size | 58.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This GJA10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 484-515 amino acids from the C-terminal region of human GJA10. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) . |
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以下是关于GJA10抗体的3篇文献示例(信息基于公开研究领域知识整理，非真实文献，仅供示例参考)：
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1. **文献名称**：*Expression and functional characterization of connexin31.3 (GJA10) in the mouse central nervous system*
**作者**：Smith A, et al.
**摘要**：本研究利用特异性GJA10抗体检测了小鼠中枢神经系统中Cx31.3(GJA10编码蛋白)的表达分布，发现其在少突胶质细胞中高表达，并揭示了其在髓鞘形成中的潜在作用。
2. **文献名称**：*GJA10 antibody validation for immunohistochemical analysis in human glioblastoma models*
**作者**：Lee J, et al.
**摘要**：文章验证了GJA10抗体在人类胶质母细胞瘤组织中的特异性，通过免疫组化(IHC)和Western blot技术证实GJA10在肿瘤边缘区显著上调，提示其可能与肿瘤侵袭性相关。
3. **文献名称**：*Role of connexin31.3 in cardiac arrhythmia: Insights from GJA10 knockout mice*
**作者**：Chen R, et al.
**摘要**：通过GJA10抗体标记，研究揭示了Cx31.3蛋白在小鼠心脏传导系统的表达缺失与心律失常表型的关联，为心脏电生理异常机制提供了新证据。
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如需真实文献，建议通过PubMed或Google Scholar搜索关键词“GJA10 antibody”或“connexin31.3 antibody”获取最新研究。
The GJA10 antibody targets the gap junction protein alpha 10 (GJA10), also known as connexin-62 (Cx62), encoded by the *GJA10* gene. Connexins are transmembrane proteins that assemble into gap junctions, intercellular channels facilitating direct exchange of ions, metabolites, and signaling molecules between adjacent cells. GJA10 belongs to the connexin family but exhibits distinct tissue-specific expression, primarily in the testes, with lower levels detected in brain, heart, and other tissues. Its role remains less characterized compared to well-studied connexins like Cx43 or Cx26. though it is implicated in spermatogenesis and cellular communication within the testicular microenvironment.
GJA10 antibodies are crucial tools for studying the protein's localization, expression patterns, and functional interactions. They enable detection via techniques such as Western blotting, immunohistochemistry, and immunofluorescence. Research using these antibodies has explored GJA10's potential involvement in reproductive health, including its regulation during germ cell development and possible associations with male infertility. Additionally, aberrant connexin expression is linked to pathologies like cancer and neurological disorders, spurring interest in GJA10's role in disease contexts. However, its precise mechanistic contributions remain under investigation, necessitating further studies to elucidate its physiological and pathological significance. Commercial GJA10 antibodies are typically validated for specificity using knockout controls or peptide-blocking assays to ensure reliability in experimental settings.
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